Partial purification and characterization of a 90,000-dalton peptide involved in activation of the eIF-2 alpha protein kinase of the hemin-controlled translational repressor

In the absence of heme, a negative translational control system is activated in reticulocytes or their lysates that causes the phosphorylation of the smallest subunit of peptide initiation factor 2 and the inhibition of peptide initiation. Two partially purified enzyme fractions are shown to give a...

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