Paradoxical Actions of Quinidine in Hyperpermeable Heart Cells

The effect of quinidine on the inotropic state was examined using small fragments of hyperpermeable ventricular muscle in vitro. In concentrations of 10 and 10 M, quinidine had no effect on the force of spontaneously contracting fibers. At a concentration of 10 M, contractile force increased by at l...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1979-01, Vol.1 (1), p.69-76
Hauptverfasser:	Wiggins, Jay R, Bloom, Sherman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cats Cell Membrane Permeability Cricetinae Egtazic Acid - pharmacology Male Mesocricetus Muscle Proteins - metabolism Myocardial Contraction - drug effects Myocardium - metabolism Quinidine - pharmacology
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Zusammenfassung:	The effect of quinidine on the inotropic state was examined using small fragments of hyperpermeable ventricular muscle in vitro. In concentrations of 10 and 10 M, quinidine had no effect on the force of spontaneously contracting fibers. At a concentration of 10 M, contractile force increased by at least twofold. We conclude that the negative inotropic action of quinidine is not by a direct action on intracellular organelles of the heart.
ISSN:	0160-2446 1533-4023
DOI:	10.1097/00005344-197901000-00007