Physostigmine-atropine solution fails to reverse diazepam sedation
Patients undergoing dental extraction under intravenous diazepam sedation were studied to determine whether physostigmine, a cholinesterase inhibitor, reverses diazepam-induced sedation. A modified Bender-Gestalt Dot Test was used to measure psychomotor function. Patient self-assessment of recovery...
Gespeichert in:
| Veröffentlicht in: | Anesthesia and analgesia 1980-01, Vol.59 (1), p.58-60 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | 1 |
| container_start_page | 58 |
| container_title | Anesthesia and analgesia |
| container_volume | 59 |
| creator | Garber, J G Ominsky, A J Orkin, F K Quinn, P |
| description | Patients undergoing dental extraction under intravenous diazepam sedation were studied to determine whether physostigmine, a cholinesterase inhibitor, reverses diazepam-induced sedation. A modified Bender-Gestalt Dot Test was used to measure psychomotor function. Patient self-assessment of recovery and a surgeon's independent assessment of recovery were scored on a 0 to 10 measured scale before and after administration of either a physostigmine-atropine mixture (nine patients) or saline (12 patients). The physostigmine-atropine mixture did not significantly speed recovery or improve psychomotor function when compared with normal saline. The results indicate that, in contradiction to previous case report, the analeptic effect of physostigmine may be specific for anticholinergic drugs. |
| doi_str_mv | 10.1213/00000539-198001000-00013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74977117</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74977117</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-822fb8e0ee546175bbb3ec03822e9e8d925eb2127c42326a2d094e0855baadc53</originalsourceid><addsrcrecordid>eNo9kE1LxDAQhnNQ1nX1Jwg5eYvmo2mSoy5-wYIe9BySdqqVtqlJK6y_3tZdd2CYD953Bh6EMKNXjDNxTeeQwhBmNKVsGsiUTByh5VQF4caYE3Sa0ue8pjpfoIViWue5WqLbl49tCmmo39u6A-KGGPqpwSk041CHDleubhIeAo7wDTEBLmv3A71rcYLSzZIzdFy5JsH5vq7Q2_3d6_qRbJ4fntY3G1KInA5Ec155DRRAZjlT0nsvoKBi2oMBXRouwXPGVZFxwXPHS2oyoFpK71xZSLFCl7u7fQxfI6TBtnUqoGlcB2FMVmVGKcbUJNQ7YRFDShEq28e6dXFrGbUzMvuPzB6Q2T9kk_Vi_2P0LZQH456X-AVa6WlP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74977117</pqid></control><display><type>article</type><title>Physostigmine-atropine solution fails to reverse diazepam sedation</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Ovid Autoload</source><creator>Garber, J G ; Ominsky, A J ; Orkin, F K ; Quinn, P</creator><creatorcontrib>Garber, J G ; Ominsky, A J ; Orkin, F K ; Quinn, P</creatorcontrib><description>Patients undergoing dental extraction under intravenous diazepam sedation were studied to determine whether physostigmine, a cholinesterase inhibitor, reverses diazepam-induced sedation. A modified Bender-Gestalt Dot Test was used to measure psychomotor function. Patient self-assessment of recovery and a surgeon's independent assessment of recovery were scored on a 0 to 10 measured scale before and after administration of either a physostigmine-atropine mixture (nine patients) or saline (12 patients). The physostigmine-atropine mixture did not significantly speed recovery or improve psychomotor function when compared with normal saline. The results indicate that, in contradiction to previous case report, the analeptic effect of physostigmine may be specific for anticholinergic drugs.</description><identifier>ISSN: 0003-2999</identifier><identifier>DOI: 10.1213/00000539-198001000-00013</identifier><identifier>PMID: 7188667</identifier><language>eng</language><publisher>United States</publisher><subject>Anesthesia, Dental - methods ; Anesthesia, Intravenous ; Atropine - pharmacology ; Diazepam - pharmacology ; Double-Blind Method ; Humans ; Motor Skills - drug effects ; Physostigmine - pharmacology ; Tooth Extraction ; Wakefulness - drug effects</subject><ispartof>Anesthesia and analgesia, 1980-01, Vol.59 (1), p.58-60</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-822fb8e0ee546175bbb3ec03822e9e8d925eb2127c42326a2d094e0855baadc53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7188667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garber, J G</creatorcontrib><creatorcontrib>Ominsky, A J</creatorcontrib><creatorcontrib>Orkin, F K</creatorcontrib><creatorcontrib>Quinn, P</creatorcontrib><title>Physostigmine-atropine solution fails to reverse diazepam sedation</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>Patients undergoing dental extraction under intravenous diazepam sedation were studied to determine whether physostigmine, a cholinesterase inhibitor, reverses diazepam-induced sedation. A modified Bender-Gestalt Dot Test was used to measure psychomotor function. Patient self-assessment of recovery and a surgeon's independent assessment of recovery were scored on a 0 to 10 measured scale before and after administration of either a physostigmine-atropine mixture (nine patients) or saline (12 patients). The physostigmine-atropine mixture did not significantly speed recovery or improve psychomotor function when compared with normal saline. The results indicate that, in contradiction to previous case report, the analeptic effect of physostigmine may be specific for anticholinergic drugs.</description><subject>Anesthesia, Dental - methods</subject><subject>Anesthesia, Intravenous</subject><subject>Atropine - pharmacology</subject><subject>Diazepam - pharmacology</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Motor Skills - drug effects</subject><subject>Physostigmine - pharmacology</subject><subject>Tooth Extraction</subject><subject>Wakefulness - drug effects</subject><issn>0003-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhnNQ1nX1Jwg5eYvmo2mSoy5-wYIe9BySdqqVtqlJK6y_3tZdd2CYD953Bh6EMKNXjDNxTeeQwhBmNKVsGsiUTByh5VQF4caYE3Sa0ue8pjpfoIViWue5WqLbl49tCmmo39u6A-KGGPqpwSk041CHDleubhIeAo7wDTEBLmv3A71rcYLSzZIzdFy5JsH5vq7Q2_3d6_qRbJ4fntY3G1KInA5Ec155DRRAZjlT0nsvoKBi2oMBXRouwXPGVZFxwXPHS2oyoFpK71xZSLFCl7u7fQxfI6TBtnUqoGlcB2FMVmVGKcbUJNQ7YRFDShEq28e6dXFrGbUzMvuPzB6Q2T9kk_Vi_2P0LZQH456X-AVa6WlP</recordid><startdate>198001</startdate><enddate>198001</enddate><creator>Garber, J G</creator><creator>Ominsky, A J</creator><creator>Orkin, F K</creator><creator>Quinn, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198001</creationdate><title>Physostigmine-atropine solution fails to reverse diazepam sedation</title><author>Garber, J G ; Ominsky, A J ; Orkin, F K ; Quinn, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-822fb8e0ee546175bbb3ec03822e9e8d925eb2127c42326a2d094e0855baadc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Anesthesia, Dental - methods</topic><topic>Anesthesia, Intravenous</topic><topic>Atropine - pharmacology</topic><topic>Diazepam - pharmacology</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Motor Skills - drug effects</topic><topic>Physostigmine - pharmacology</topic><topic>Tooth Extraction</topic><topic>Wakefulness - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garber, J G</creatorcontrib><creatorcontrib>Ominsky, A J</creatorcontrib><creatorcontrib>Orkin, F K</creatorcontrib><creatorcontrib>Quinn, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garber, J G</au><au>Ominsky, A J</au><au>Orkin, F K</au><au>Quinn, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physostigmine-atropine solution fails to reverse diazepam sedation</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1980-01</date><risdate>1980</risdate><volume>59</volume><issue>1</issue><spage>58</spage><epage>60</epage><pages>58-60</pages><issn>0003-2999</issn><abstract>Patients undergoing dental extraction under intravenous diazepam sedation were studied to determine whether physostigmine, a cholinesterase inhibitor, reverses diazepam-induced sedation. A modified Bender-Gestalt Dot Test was used to measure psychomotor function. Patient self-assessment of recovery and a surgeon's independent assessment of recovery were scored on a 0 to 10 measured scale before and after administration of either a physostigmine-atropine mixture (nine patients) or saline (12 patients). The physostigmine-atropine mixture did not significantly speed recovery or improve psychomotor function when compared with normal saline. The results indicate that, in contradiction to previous case report, the analeptic effect of physostigmine may be specific for anticholinergic drugs.</abstract><cop>United States</cop><pmid>7188667</pmid><doi>10.1213/00000539-198001000-00013</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2999 |
| ispartof | Anesthesia and analgesia, 1980-01, Vol.59 (1), p.58-60 |
| issn | 0003-2999 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74977117 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Anesthesia, Dental - methods Anesthesia, Intravenous Atropine - pharmacology Diazepam - pharmacology Double-Blind Method Humans Motor Skills - drug effects Physostigmine - pharmacology Tooth Extraction Wakefulness - drug effects |
| title | Physostigmine-atropine solution fails to reverse diazepam sedation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T13%3A10%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physostigmine-atropine%20solution%20fails%20to%20reverse%20diazepam%20sedation&rft.jtitle=Anesthesia%20and%20analgesia&rft.au=Garber,%20J%20G&rft.date=1980-01&rft.volume=59&rft.issue=1&rft.spage=58&rft.epage=60&rft.pages=58-60&rft.issn=0003-2999&rft_id=info:doi/10.1213/00000539-198001000-00013&rft_dat=%3Cproquest_cross%3E74977117%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74977117&rft_id=info:pmid/7188667&rfr_iscdi=true |