Intravitreal Autotransplantation of Fibroblasts
Tissue cultured skin fibroblasts autotransplanted into the vitreous cavity of rabbit eyes formed intravitreal strands that grew toward the medullary ray and optic nerve head and caused preretinal puckers and traction detachment. After four weeks, 32 of 51 eyes (63%) developed these changes. Light an...
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| Veröffentlicht in: | American journal of ophthalmology 1980-01, Vol.89 (1), p.121-130 |
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| container_title | American journal of ophthalmology |
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| creator | Sugita, Gentaro Tano, Yasuo Machemer, Robert Abrams, Gary Claflin, Alice Fiorentino, Gilbert |
| description | Tissue cultured skin fibroblasts autotransplanted into the vitreous cavity of rabbit eyes formed intravitreal strands that grew toward the medullary ray and optic nerve head and caused preretinal puckers and traction detachment. After four weeks, 32 of 51 eyes (63%) developed these changes. Light and electron microscopy revealed initial cell death. Remaining cells aligned themselves quickly into strands and began to multiply as shown by tritiated thymidine methyl incorporation. The appearance of cells that resemble myofibroblasts may explain the contractability of the strand. Because the effect of intraocular proliferation can be quantitated by the number of puckers and retinal detachments developing, this model may be useful for the study of therapeutic means to reduce intraocular proliferation. |
| doi_str_mv | 10.1016/0002-9394(80)90238-X |
| format | Article |
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After four weeks, 32 of 51 eyes (63%) developed these changes. Light and electron microscopy revealed initial cell death. Remaining cells aligned themselves quickly into strands and began to multiply as shown by tritiated thymidine methyl incorporation. The appearance of cells that resemble myofibroblasts may explain the contractability of the strand. Because the effect of intraocular proliferation can be quantitated by the number of puckers and retinal detachments developing, this model may be useful for the study of therapeutic means to reduce intraocular proliferation.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/0002-9394(80)90238-X</identifier><identifier>PMID: 7356777</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cells, Cultured ; Cicatrix - pathology ; Fibroblasts - transplantation ; Fibroblasts - ultrastructure ; Rabbits ; Retinal Detachment - etiology ; Retinal Detachment - pathology ; Transplantation, Autologous ; Vitreous Body - pathology</subject><ispartof>American journal of ophthalmology, 1980-01, Vol.89 (1), p.121-130</ispartof><rights>1980 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-c43497863236e42ae4a3e01ceaeb2c205d63abddd39d17a4544bcaa61d57913c3</citedby><cites>FETCH-LOGICAL-c272t-c43497863236e42ae4a3e01ceaeb2c205d63abddd39d17a4544bcaa61d57913c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000293948090238X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7356777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugita, Gentaro</creatorcontrib><creatorcontrib>Tano, Yasuo</creatorcontrib><creatorcontrib>Machemer, Robert</creatorcontrib><creatorcontrib>Abrams, Gary</creatorcontrib><creatorcontrib>Claflin, Alice</creatorcontrib><creatorcontrib>Fiorentino, Gilbert</creatorcontrib><title>Intravitreal Autotransplantation of Fibroblasts</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Tissue cultured skin fibroblasts autotransplanted into the vitreous cavity of rabbit eyes formed intravitreal strands that grew toward the medullary ray and optic nerve head and caused preretinal puckers and traction detachment. After four weeks, 32 of 51 eyes (63%) developed these changes. Light and electron microscopy revealed initial cell death. Remaining cells aligned themselves quickly into strands and began to multiply as shown by tritiated thymidine methyl incorporation. The appearance of cells that resemble myofibroblasts may explain the contractability of the strand. Because the effect of intraocular proliferation can be quantitated by the number of puckers and retinal detachments developing, this model may be useful for the study of therapeutic means to reduce intraocular proliferation.</description><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Cicatrix - pathology</subject><subject>Fibroblasts - transplantation</subject><subject>Fibroblasts - ultrastructure</subject><subject>Rabbits</subject><subject>Retinal Detachment - etiology</subject><subject>Retinal Detachment - pathology</subject><subject>Transplantation, Autologous</subject><subject>Vitreous Body - pathology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotVa_gUJPooe1-bfJ5iKUYrVQ8KLQW8gmU4hsNzXJFvz2bm3p0dMwvDdvZn4I3RL8RDARE4wxLRRT_KHCjwpTVhWrMzQklVQFqRQ5R8OT5RJdpfTVt0JyOUADyUohpRyiyaLN0ex8jmCa8bTLoW_btG1Mm032oR2H9Xju6xjqxqScrtHF2jQJbo51hD7nLx-zt2L5_rqYTZeFpZLmwnLGlawEo0wApwa4YYCJBQM1tRSXTjBTO-eYckQaXnJeW2MEcaVUhFk2QveH3G0M3x2krDc-WWj6uyB0SUuuREVV2Rv5wWhjSCnCWm-j35j4ownWe056D0HvIegK6z9OetWP3R3zu3oD7jR0BNPrzwcd-id3HqJO1kNrwfkINmsX_P8LfgGmKXds</recordid><startdate>198001</startdate><enddate>198001</enddate><creator>Sugita, Gentaro</creator><creator>Tano, Yasuo</creator><creator>Machemer, Robert</creator><creator>Abrams, Gary</creator><creator>Claflin, Alice</creator><creator>Fiorentino, Gilbert</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198001</creationdate><title>Intravitreal Autotransplantation of Fibroblasts</title><author>Sugita, Gentaro ; Tano, Yasuo ; Machemer, Robert ; Abrams, Gary ; Claflin, Alice ; Fiorentino, Gilbert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-c43497863236e42ae4a3e01ceaeb2c205d63abddd39d17a4544bcaa61d57913c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Cells, Cultured</topic><topic>Cicatrix - pathology</topic><topic>Fibroblasts - transplantation</topic><topic>Fibroblasts - ultrastructure</topic><topic>Rabbits</topic><topic>Retinal Detachment - etiology</topic><topic>Retinal Detachment - pathology</topic><topic>Transplantation, Autologous</topic><topic>Vitreous Body - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugita, Gentaro</creatorcontrib><creatorcontrib>Tano, Yasuo</creatorcontrib><creatorcontrib>Machemer, Robert</creatorcontrib><creatorcontrib>Abrams, Gary</creatorcontrib><creatorcontrib>Claflin, Alice</creatorcontrib><creatorcontrib>Fiorentino, Gilbert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugita, Gentaro</au><au>Tano, Yasuo</au><au>Machemer, Robert</au><au>Abrams, Gary</au><au>Claflin, Alice</au><au>Fiorentino, Gilbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravitreal Autotransplantation of Fibroblasts</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1980-01</date><risdate>1980</risdate><volume>89</volume><issue>1</issue><spage>121</spage><epage>130</epage><pages>121-130</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>Tissue cultured skin fibroblasts autotransplanted into the vitreous cavity of rabbit eyes formed intravitreal strands that grew toward the medullary ray and optic nerve head and caused preretinal puckers and traction detachment. After four weeks, 32 of 51 eyes (63%) developed these changes. Light and electron microscopy revealed initial cell death. Remaining cells aligned themselves quickly into strands and began to multiply as shown by tritiated thymidine methyl incorporation. The appearance of cells that resemble myofibroblasts may explain the contractability of the strand. Because the effect of intraocular proliferation can be quantitated by the number of puckers and retinal detachments developing, this model may be useful for the study of therapeutic means to reduce intraocular proliferation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7356777</pmid><doi>10.1016/0002-9394(80)90238-X</doi><tpages>10</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1980-01, Vol.89 (1), p.121-130 |
| issn | 0002-9394 1879-1891 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cells, Cultured Cicatrix - pathology Fibroblasts - transplantation Fibroblasts - ultrastructure Rabbits Retinal Detachment - etiology Retinal Detachment - pathology Transplantation, Autologous Vitreous Body - pathology |
| title | Intravitreal Autotransplantation of Fibroblasts |
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