Comparison of methionine-enkephalin and morphine in the stimulation of gastric acid secretion in the dog

In dogs with Heidenhain pouches and gastric fistulas, we studied acid secretion in response to systemic or portal infusion of methionine-enkephalin (met-enkephalin), enkephalin-analog, or morphine. All these opiate compounds caused a dose-dependent increase in acid secretion under basal conditions a...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1980-02, Vol.78 (2), p.294-300
Hauptverfasser:	Konturek, Stanisław J., Tasler, Janina, Cieszkowski, Marek, Mikoś, Emilia, Coy, David H., Schally, Andrew V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dogs Dose-Response Relationship, Drug Endorphins - pharmacology Enkephalins - pharmacology Gastric Juice - secretion Gastric Mucosa - blood supply Gastric Mucosa - drug effects Gastrins - blood Morphine - pharmacology Naloxone - pharmacology Pentagastrin - pharmacology Receptors, Cholinergic - drug effects Receptors, Histamine H2 - drug effects Receptors, Opioid - drug effects Regional Blood Flow - drug effects
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