MIF-I's differential actions as an opiate antagonist

The effects of MIF-I (Pro-Leu-Gly-NH 2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I d...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1979-12, Vol.11 (6), p.721-723
Hauptverfasser:	Kastin, Abba J., Olson, Richard D., Ehrensing, Rudolph H., Berzas, Matthew C., Schally, Andrew V., Coy, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Animals Feeding Behavior - drug effects Food intake Hypothalamus, Middle - physiology In Vitro Techniques Male Mice MIF-I MSH Release-Inhibiting Hormone - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Naloxone - pharmacology Narcotic Antagonists Opiate Peptide Reaction Time - drug effects Receptor Vas deferens
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Zusammenfassung:	The effects of MIF-I (Pro-Leu-Gly-NH 2) were examined in three experimental conditions in which the opiate antagonist naloxone is active. MIF-I was found to block the analgesic effects of enkephalins and also morphine in the tail-flick test but not in the vas deferens assay. Unlike naloxone, MIF-I did not seem to reduce food intake in VMH-lesioned rats. The results suggest the possibility that MIF-I may represent a class of naturally occurring opiate antagonists with varying activities in independent situations.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(79)90270-3