Rates of release of subcutaneously injected antigens in the rat. Comparison of an aqueous preparation with two alum-precipated preparations
Release of antigen E-125 I from the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing 1.0-1.2 mg of Al/ml was administered rather than an aqueous preparation. The rates of 125I excretion were similarly influenced being...
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| Veröffentlicht in: | Allergy (Copenhagen) 1979-10, Vol.34 (5), p.339-344 |
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| container_issue | 5 |
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| container_title | Allergy (Copenhagen) |
| container_volume | 34 |
| creator | Leeling, J L Muni, I A Helms, R J Johnson, Jr, N |
| description | Release of antigen E-125 I from the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing 1.0-1.2 mg of Al/ml was administered rather than an aqueous preparation. The rates of 125I excretion were similarly influenced being statistically slower through the first week after single doses of the alum-precipitated preparations. The results of these studies strongly support the view that alum-precipitated vaccines offer more protection from system reactions than aqueous vaccines. |
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The results of these studies strongly support the view that alum-precipitated vaccines offer more protection from system reactions than aqueous vaccines.</description><identifier>ISSN: 0105-4538</identifier><identifier>PMID: 546250</identifier><language>eng</language><publisher>Denmark</publisher><subject>Absorption ; Allergens - administration & dosage ; Allergens - pharmacology ; Alum Compounds - administration & dosage ; Aluminum - administration & dosage ; Animals ; Antigens - administration & dosage ; Injections, Subcutaneous ; Iodine Radioisotopes ; Male ; Plant Extracts - administration & dosage ; Rats ; Rats, Inbred Strains ; Research Design</subject><ispartof>Allergy (Copenhagen), 1979-10, Vol.34 (5), p.339-344</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/546250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leeling, J L</creatorcontrib><creatorcontrib>Muni, I A</creatorcontrib><creatorcontrib>Helms, R J</creatorcontrib><creatorcontrib>Johnson, Jr, N</creatorcontrib><title>Rates of release of subcutaneously injected antigens in the rat. Comparison of an aqueous preparation with two alum-precipated preparations</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Release of antigen E-125 I from the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing 1.0-1.2 mg of Al/ml was administered rather than an aqueous preparation. The rates of 125I excretion were similarly influenced being statistically slower through the first week after single doses of the alum-precipitated preparations. The results of these studies strongly support the view that alum-precipitated vaccines offer more protection from system reactions than aqueous vaccines.</description><subject>Absorption</subject><subject>Allergens - administration & dosage</subject><subject>Allergens - pharmacology</subject><subject>Alum Compounds - administration & dosage</subject><subject>Aluminum - administration & dosage</subject><subject>Animals</subject><subject>Antigens - administration & dosage</subject><subject>Injections, Subcutaneous</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Plant Extracts - administration & dosage</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Research Design</subject><issn>0105-4538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtqwzAQRbXoK037B11o1Z2LbEmWvCyhLwgUSvZmLI8bBb-qByHf0J-ujbPoaoY5915m5oKsWMpkIiTXN-TW-wNjTGUFuyZXUuSZZCvy-wUBPR0a6rBF8Di3PlYmBuhxiL49Udsf0ASsKfTBfmPvpwkNe6QOwhPdDN0Izvqhn63QU_iJs5GODicAwU7kaMOehuNAoY1dMhFjR5gj_4n8HblsoPV4f65rsnt92W3ek-3n28fmeZuMMmMJiFRUEitV8Do1Uus654YD1BpyBYURTc2VFrKoQKWiYXmqJW-kUkJjqpXka_K4xI5umFb1oeysN9i2y8GlEgVXivFJ-HAWxqrDuhyd7cCdyuV3_A_A12yL</recordid><startdate>197910</startdate><enddate>197910</enddate><creator>Leeling, J L</creator><creator>Muni, I A</creator><creator>Helms, R J</creator><creator>Johnson, Jr, N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197910</creationdate><title>Rates of release of subcutaneously injected antigens in the rat. 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Comparison of an aqueous preparation with two alum-precipated preparations</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>1979-10</date><risdate>1979</risdate><volume>34</volume><issue>5</issue><spage>339</spage><epage>344</epage><pages>339-344</pages><issn>0105-4538</issn><abstract>Release of antigen E-125 I from the site of subcutaneous injection in male rats was delayed significantly when either of two alum-precipitated preparations containing 1.0-1.2 mg of Al/ml was administered rather than an aqueous preparation. The rates of 125I excretion were similarly influenced being statistically slower through the first week after single doses of the alum-precipitated preparations. The results of these studies strongly support the view that alum-precipitated vaccines offer more protection from system reactions than aqueous vaccines.</abstract><cop>Denmark</cop><pmid>546250</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0105-4538 |
| ispartof | Allergy (Copenhagen), 1979-10, Vol.34 (5), p.339-344 |
| issn | 0105-4538 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74937703 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Absorption Allergens - administration & dosage Allergens - pharmacology Alum Compounds - administration & dosage Aluminum - administration & dosage Animals Antigens - administration & dosage Injections, Subcutaneous Iodine Radioisotopes Male Plant Extracts - administration & dosage Rats Rats, Inbred Strains Research Design |
| title | Rates of release of subcutaneously injected antigens in the rat. Comparison of an aqueous preparation with two alum-precipated preparations |
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