The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression
A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin. It was discovered that 100% of these subjects had chronic pain complaints, most of which paralleled the course of depress...
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| Veröffentlicht in: | Pain (Amsterdam) 1979-12, Vol.7 (3), p.331-341 |
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| container_end_page | 341 |
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| container_title | Pain (Amsterdam) |
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| creator | Ward, Nicholas G. Bloom, Valerie L. Friedel, Robert O. |
| description | A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin. It was discovered that 100% of these subjects had chronic pain complaints, most of which paralleled the course of depression. Headache was most commonly noted. Doxepin's analgesic effects were intimately associated with its antidepressant effects. There was a highly significant relationship between improvement of depression and reduction of pain on doxepin (
P < 0.005). Conversely, patients who obtained minimal antidepressant effect also obtained minimal analgesic effect. Psychophysiologic and biochemical hypotheses of this association of pain and depression are discussed. |
| doi_str_mv | 10.1016/0304-3959(79)90089-7 |
| format | Article |
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P < 0.005). Conversely, patients who obtained minimal antidepressant effect also obtained minimal analgesic effect. Psychophysiologic and biochemical hypotheses of this association of pain and depression are discussed.</description><subject>Chronic Disease</subject><subject>Depression - complications</subject><subject>Depression - drug therapy</subject><subject>Doxepin - therapeutic use</subject><subject>Headache - complications</subject><subject>Humans</subject><subject>Pain - complications</subject><subject>Pain - drug therapy</subject><subject>Placebos</subject><issn>0304-3959</issn><issn>1872-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOGzEYha0KWkLKG2Qxq4ouBn5fZhxvKiFEWyQkNuna8tj_NG4nntR2uLx9PSSCHSvfzndkfyZkQeGCAm0vgYOouWrUuVRfFcBS1fIDmdGlZHXbMn5EZq-RE3Ka0h8AYIypT-Rjw0FyNSNmtcYK-x5t9g8YMKVq7KscvX22g7eVCdk73MZyUKap8qHKhcgRTd5gyFPajvjkU_bhd7U1JWCCqw6MH8NnctybIeHZYZyTX99vVtc_67v7H7fXV3e1FZTKckluBBcoHQiHfQfYNRYRGyZY14olsI4h7wQKKaTlSwd971qruAUmlGn4nHzZ927j-G-HKeuNTxaHwQQcd0lLoThvy6vnROyDNo4pRez1NvqNic-agp7E6smanqxpqfSLWD1hi0P_rtuge4X2Jt9aH8chY0x_h90jRr1GM-S1LuKh5aqtqZKKsrKqp62p9dsew6LmwRciWY_BovOx_Il2o3__Wv8BIDOYvA</recordid><startdate>19791201</startdate><enddate>19791201</enddate><creator>Ward, Nicholas G.</creator><creator>Bloom, Valerie L.</creator><creator>Friedel, Robert O.</creator><general>Elsevier B.V</general><general>Lippincott-Raven Publishers.Copyright Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19791201</creationdate><title>The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression</title><author>Ward, Nicholas G. ; Bloom, Valerie L. ; Friedel, Robert O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4117-393a434e7d04defb0eb5ceee5242b64802b2e3b4e4747c38d0ffd6c93c0249a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Chronic Disease</topic><topic>Depression - complications</topic><topic>Depression - drug therapy</topic><topic>Doxepin - therapeutic use</topic><topic>Headache - complications</topic><topic>Humans</topic><topic>Pain - complications</topic><topic>Pain - drug therapy</topic><topic>Placebos</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ward, Nicholas G.</creatorcontrib><creatorcontrib>Bloom, Valerie L.</creatorcontrib><creatorcontrib>Friedel, Robert O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pain (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ward, Nicholas G.</au><au>Bloom, Valerie L.</au><au>Friedel, Robert O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression</atitle><jtitle>Pain (Amsterdam)</jtitle><addtitle>Pain</addtitle><date>1979-12-01</date><risdate>1979</risdate><volume>7</volume><issue>3</issue><spage>331</spage><epage>341</epage><pages>331-341</pages><issn>0304-3959</issn><eissn>1872-6623</eissn><abstract>A group of moderately to severely depressed individuals with moderate anxiety were studied to determine the frequency and nature of pain complaints and their response to doxepin. It was discovered that 100% of these subjects had chronic pain complaints, most of which paralleled the course of depression. Headache was most commonly noted. Doxepin's analgesic effects were intimately associated with its antidepressant effects. There was a highly significant relationship between improvement of depression and reduction of pain on doxepin (
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| fulltext | fulltext |
| identifier | ISSN: 0304-3959 |
| ispartof | Pain (Amsterdam), 1979-12, Vol.7 (3), p.331-341 |
| issn | 0304-3959 1872-6623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74933607 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Chronic Disease Depression - complications Depression - drug therapy Doxepin - therapeutic use Headache - complications Humans Pain - complications Pain - drug therapy Placebos |
| title | The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression |
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