Analysis of 1, 4-Dimorpholino-7-phenylpyrido [3, 4-d] pyridazine (DS-511) and Its Metabolites in Biological Specimens. I. Identification of Metabolites in Rat Urine and Dog Urine and Bile

The metabolic fate of 1, 4-dimorpholino-7-phenylpyrido [3, 4-d] pyridazine (DS-511) was studied in the rat and the dog. Urine and bile were extracted with ethyl acetate before and after enzymatic hydrolysis and separated into lipophilic and hydrophilic fractions. The structures of seven lipophilic a...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1979/07/25, Vol.27(7), pp.1544-1552
Hauptverfasser:	KUWAYAMA, MOTOAKI, MIYAKE, SOHACHIRO, OMURA, KIYOSHI, ITAKURA, KOICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - analysis Dogs gas chromatography-mass spectrometry Male Morpholines - metabolism Morpholines - urine Pyridazines - metabolism Pyridazines - urine Rats
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