Axon elongation: Effect of nerve growth factor on microtubule protein

Nerve growth factor (NGF) causes a rapid outgrowth of axons from dorsal root ganglia in vitro. Abundant microtubules are found in such axons, as well as in axons of control ganglia not treated with NGF. Using the colchicine-binding assay for microtubule protein, it was found that NGF treatment does...

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Veröffentlicht in:	Experimental cell research 1971-01, Vol.66 (2), p.346-352
Hauptverfasser:	Yamada, K.M., Wessells, N.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - cytology Axons - drug effects Axons - growth & development Chick Embryo Colchicine - metabolism Culture Techniques Ganglia - cytology Ganglia - drug effects Ganglia - metabolism Growth Substances - pharmacology Histocytochemistry Leucine - metabolism Microscopy, Electron Microtubules - analysis Microtubules - drug effects Nerve Growth Factors - pharmacology Organoids - drug effects Protein Biosynthesis Proteins - analysis Puromycin - pharmacology Time Factors Tritium
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