PHARMACOLOGICAL STUDIES OF LYCORENINE, AN ALKALOID OF LYCORIS RADIATA HERB.: VASODEPRESSOR MECHANISM IN RATS
Vasodepressor mechanism of lycorenine (an alkaloid of Lycoris radiata Herb.) was investigated in anesthetized rats. Lycorenine (1-10 mg/kg i.v.) produced dose-related decreases in blood pressure and heart rate and tachyphylaxis developed with repeated injections. In the blood-perfused rat hindquarte...
Gespeichert in:
| Veröffentlicht in: | Japanese journal of pharmacology 1979, Vol.29(4), pp.605-622 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 622 |
|---|---|
| container_issue | 4 |
| container_start_page | 605 |
| container_title | Japanese journal of pharmacology |
| container_volume | 29 |
| creator | MIYASAKA, Katsuhiko HIRAMATSLJ, Yoshio TAKEZAKP, Takayuki |
| description | Vasodepressor mechanism of lycorenine (an alkaloid of Lycoris radiata Herb.) was investigated in anesthetized rats. Lycorenine (1-10 mg/kg i.v.) produced dose-related decreases in blood pressure and heart rate and tachyphylaxis developed with repeated injections. In the blood-perfused rat hindquarters, lycorenine (62.5- 500 pg i.a.) produced dose-related decreases both in mean blood pressure and in perfusion pressure, and the lycorenine-induced decrease in perfusion pressure was abolished by phenoxybenzamine or hexamOthonium. Lycorenine (more than 1 mg/kg i.v.) blocked the pressor response to sympathetic nerve stimulation, but failed to block the tachycardia induced by sympathetic nerve stimulation. Lycorenine (7.5 or 15 mg/kg i.v.) reduced the spontaneous splanchnic nerve activity. Lycorenine when given intracerebroventricularly produced decreases in blood pressure and heart rate only in large doses (over 500 /μg). The maximal bradycardia induced by lycorenine was abolished by bilateral vagotomy. It is suggested that lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. |
| doi_str_mv | 10.1254/jjp.29.605 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74912739</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021519819529973</els_id><sourcerecordid>74912739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c615t-7dd2107d11657742a39e4b4edb5af4ae447d2eaa8e48e3f1fcb08e8f5baf9f653</originalsourceid><addsrcrecordid>eNptkE2vlDAUhhvj13h149pFVy6MjBRaCndXgesQGbiBuSaumgIHL4T5sGVM_Pf2hsms3PSked485-RF6D1x18Rj9Ms4ntZetA5c9gytiE-54zM3eI5WrusRh5EofI3eGDPab-gS-gq9ZD73eLBC0_1GVFsRl3n5LYtFjuvdQ5KlNS7vcP4zLqu0yIr0MxYFFvl3kZdZckVZjSuRZGIn8Catvq5v8Q9Rl0l6X6V1XVZ4m8YbUWT1FmeFTe7qt-hFryYD7y7zBj3cpbt441yWO21A2OzwrvOIyztCAsY59ZQfAW0odA1TPVVAKe88UCoEGoLfk75t3BDCnjWqj_qA-Tfo4-I96ePvM5hZ7gfTwjSpAxzPRnIaEY_7kQ1-WoKtPhqjoZcnPeyV_iuJK5-albZZ6UXSNmvDHy7Wc7OH7hpdqrQ4WfBoZvULrljpeWgnkOPp0ZCIkScdXR5rveL2UWkJB6uhiwZsQX8G0NK0Axxa6AYN7Sy74_C_4_4BpGuVZw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74912739</pqid></control><display><type>article</type><title>PHARMACOLOGICAL STUDIES OF LYCORENINE, AN ALKALOID OF LYCORIS RADIATA HERB.: VASODEPRESSOR MECHANISM IN RATS</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>MIYASAKA, Katsuhiko ; HIRAMATSLJ, Yoshio ; TAKEZAKP, Takayuki</creator><creatorcontrib>MIYASAKA, Katsuhiko ; HIRAMATSLJ, Yoshio ; TAKEZAKP, Takayuki</creatorcontrib><description>Vasodepressor mechanism of lycorenine (an alkaloid of Lycoris radiata Herb.) was investigated in anesthetized rats. Lycorenine (1-10 mg/kg i.v.) produced dose-related decreases in blood pressure and heart rate and tachyphylaxis developed with repeated injections. In the blood-perfused rat hindquarters, lycorenine (62.5- 500 pg i.a.) produced dose-related decreases both in mean blood pressure and in perfusion pressure, and the lycorenine-induced decrease in perfusion pressure was abolished by phenoxybenzamine or hexamOthonium. Lycorenine (more than 1 mg/kg i.v.) blocked the pressor response to sympathetic nerve stimulation, but failed to block the tachycardia induced by sympathetic nerve stimulation. Lycorenine (7.5 or 15 mg/kg i.v.) reduced the spontaneous splanchnic nerve activity. Lycorenine when given intracerebroventricularly produced decreases in blood pressure and heart rate only in large doses (over 500 /μg). The maximal bradycardia induced by lycorenine was abolished by bilateral vagotomy. It is suggested that lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.29.605</identifier><identifier>PMID: 537276</identifier><language>eng</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Action Potentials - drug effects ; Alkaloids - administration & dosage ; Alkaloids - pharmacology ; Amaryllidaceae Alkaloids ; Animals ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Depression, Chemical ; Electric Stimulation ; Female ; Guinea Pigs ; Heart Rate - drug effects ; In Vitro Techniques ; Male ; Muscle, Smooth - drug effects ; Papaverine - pharmacology ; Perfusion ; Plants, Medicinal - analysis ; Rats ; Splanchnic Nerves - drug effects ; Sympathetic Nervous System - physiology ; Tachyphylaxis ; Vagotomy</subject><ispartof>The Japanese Journal of Pharmacology, 1979, Vol.29(4), pp.605-622</ispartof><rights>1979 Elsevier B.V.</rights><rights>The Japanese PharmacologicalSociety</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c615t-7dd2107d11657742a39e4b4edb5af4ae447d2eaa8e48e3f1fcb08e8f5baf9f653</citedby><cites>FETCH-LOGICAL-c615t-7dd2107d11657742a39e4b4edb5af4ae447d2eaa8e48e3f1fcb08e8f5baf9f653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/537276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIYASAKA, Katsuhiko</creatorcontrib><creatorcontrib>HIRAMATSLJ, Yoshio</creatorcontrib><creatorcontrib>TAKEZAKP, Takayuki</creatorcontrib><title>PHARMACOLOGICAL STUDIES OF LYCORENINE, AN ALKALOID OF LYCORIS RADIATA HERB.: VASODEPRESSOR MECHANISM IN RATS</title><title>Japanese journal of pharmacology</title><addtitle>Jpn.J.Pharmacol.</addtitle><description>Vasodepressor mechanism of lycorenine (an alkaloid of Lycoris radiata Herb.) was investigated in anesthetized rats. Lycorenine (1-10 mg/kg i.v.) produced dose-related decreases in blood pressure and heart rate and tachyphylaxis developed with repeated injections. In the blood-perfused rat hindquarters, lycorenine (62.5- 500 pg i.a.) produced dose-related decreases both in mean blood pressure and in perfusion pressure, and the lycorenine-induced decrease in perfusion pressure was abolished by phenoxybenzamine or hexamOthonium. Lycorenine (more than 1 mg/kg i.v.) blocked the pressor response to sympathetic nerve stimulation, but failed to block the tachycardia induced by sympathetic nerve stimulation. Lycorenine (7.5 or 15 mg/kg i.v.) reduced the spontaneous splanchnic nerve activity. Lycorenine when given intracerebroventricularly produced decreases in blood pressure and heart rate only in large doses (over 500 /μg). The maximal bradycardia induced by lycorenine was abolished by bilateral vagotomy. It is suggested that lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity.</description><subject>Action Potentials - drug effects</subject><subject>Alkaloids - administration & dosage</subject><subject>Alkaloids - pharmacology</subject><subject>Amaryllidaceae Alkaloids</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Depression, Chemical</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle, Smooth - drug effects</subject><subject>Papaverine - pharmacology</subject><subject>Perfusion</subject><subject>Plants, Medicinal - analysis</subject><subject>Rats</subject><subject>Splanchnic Nerves - drug effects</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Tachyphylaxis</subject><subject>Vagotomy</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE2vlDAUhhvj13h149pFVy6MjBRaCndXgesQGbiBuSaumgIHL4T5sGVM_Pf2hsms3PSked485-RF6D1x18Rj9Ms4ntZetA5c9gytiE-54zM3eI5WrusRh5EofI3eGDPab-gS-gq9ZD73eLBC0_1GVFsRl3n5LYtFjuvdQ5KlNS7vcP4zLqu0yIr0MxYFFvl3kZdZckVZjSuRZGIn8Catvq5v8Q9Rl0l6X6V1XVZ4m8YbUWT1FmeFTe7qt-hFryYD7y7zBj3cpbt441yWO21A2OzwrvOIyztCAsY59ZQfAW0odA1TPVVAKe88UCoEGoLfk75t3BDCnjWqj_qA-Tfo4-I96ePvM5hZ7gfTwjSpAxzPRnIaEY_7kQ1-WoKtPhqjoZcnPeyV_iuJK5-albZZ6UXSNmvDHy7Wc7OH7hpdqrQ4WfBoZvULrljpeWgnkOPp0ZCIkScdXR5rveL2UWkJB6uhiwZsQX8G0NK0Axxa6AYN7Sy74_C_4_4BpGuVZw</recordid><startdate>19790101</startdate><enddate>19790101</enddate><creator>MIYASAKA, Katsuhiko</creator><creator>HIRAMATSLJ, Yoshio</creator><creator>TAKEZAKP, Takayuki</creator><general>The Japanese Pharmacological Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790101</creationdate><title>PHARMACOLOGICAL STUDIES OF LYCORENINE, AN ALKALOID OF LYCORIS RADIATA HERB.: VASODEPRESSOR MECHANISM IN RATS</title><author>MIYASAKA, Katsuhiko ; HIRAMATSLJ, Yoshio ; TAKEZAKP, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-7dd2107d11657742a39e4b4edb5af4ae447d2eaa8e48e3f1fcb08e8f5baf9f653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Action Potentials - drug effects</topic><topic>Alkaloids - administration & dosage</topic><topic>Alkaloids - pharmacology</topic><topic>Amaryllidaceae Alkaloids</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Depression, Chemical</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Heart Rate - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle, Smooth - drug effects</topic><topic>Papaverine - pharmacology</topic><topic>Perfusion</topic><topic>Plants, Medicinal - analysis</topic><topic>Rats</topic><topic>Splanchnic Nerves - drug effects</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Tachyphylaxis</topic><topic>Vagotomy</topic><toplevel>online_resources</toplevel><creatorcontrib>MIYASAKA, Katsuhiko</creatorcontrib><creatorcontrib>HIRAMATSLJ, Yoshio</creatorcontrib><creatorcontrib>TAKEZAKP, Takayuki</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIYASAKA, Katsuhiko</au><au>HIRAMATSLJ, Yoshio</au><au>TAKEZAKP, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PHARMACOLOGICAL STUDIES OF LYCORENINE, AN ALKALOID OF LYCORIS RADIATA HERB.: VASODEPRESSOR MECHANISM IN RATS</atitle><jtitle>Japanese journal of pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>1979-01-01</date><risdate>1979</risdate><volume>29</volume><issue>4</issue><spage>605</spage><epage>622</epage><pages>605-622</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><abstract>Vasodepressor mechanism of lycorenine (an alkaloid of Lycoris radiata Herb.) was investigated in anesthetized rats. Lycorenine (1-10 mg/kg i.v.) produced dose-related decreases in blood pressure and heart rate and tachyphylaxis developed with repeated injections. In the blood-perfused rat hindquarters, lycorenine (62.5- 500 pg i.a.) produced dose-related decreases both in mean blood pressure and in perfusion pressure, and the lycorenine-induced decrease in perfusion pressure was abolished by phenoxybenzamine or hexamOthonium. Lycorenine (more than 1 mg/kg i.v.) blocked the pressor response to sympathetic nerve stimulation, but failed to block the tachycardia induced by sympathetic nerve stimulation. Lycorenine (7.5 or 15 mg/kg i.v.) reduced the spontaneous splanchnic nerve activity. Lycorenine when given intracerebroventricularly produced decreases in blood pressure and heart rate only in large doses (over 500 /μg). The maximal bradycardia induced by lycorenine was abolished by bilateral vagotomy. It is suggested that lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>537276</pmid><doi>10.1254/jjp.29.605</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-5198 |
| ispartof | The Japanese Journal of Pharmacology, 1979, Vol.29(4), pp.605-622 |
| issn | 0021-5198 1347-3506 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74912739 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Action Potentials - drug effects Alkaloids - administration & dosage Alkaloids - pharmacology Amaryllidaceae Alkaloids Animals Blood Pressure - drug effects Cardiac Output - drug effects Depression, Chemical Electric Stimulation Female Guinea Pigs Heart Rate - drug effects In Vitro Techniques Male Muscle, Smooth - drug effects Papaverine - pharmacology Perfusion Plants, Medicinal - analysis Rats Splanchnic Nerves - drug effects Sympathetic Nervous System - physiology Tachyphylaxis Vagotomy |
| title | PHARMACOLOGICAL STUDIES OF LYCORENINE, AN ALKALOID OF LYCORIS RADIATA HERB.: VASODEPRESSOR MECHANISM IN RATS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T17%3A53%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PHARMACOLOGICAL%20STUDIES%20OF%20LYCORENINE,%20AN%20ALKALOID%20OF%20LYCORIS%20RADIATA%20HERB.:%20VASODEPRESSOR%20MECHANISM%20IN%20RATS&rft.jtitle=Japanese%20journal%20of%20pharmacology&rft.au=MIYASAKA,%20Katsuhiko&rft.date=1979-01-01&rft.volume=29&rft.issue=4&rft.spage=605&rft.epage=622&rft.pages=605-622&rft.issn=0021-5198&rft.eissn=1347-3506&rft_id=info:doi/10.1254/jjp.29.605&rft_dat=%3Cproquest_cross%3E74912739%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74912739&rft_id=info:pmid/537276&rft_els_id=S0021519819529973&rfr_iscdi=true |