Influence of magnesium on the secretion and action of parathyroid hormone
The interactions of serum levels of magnesium and parathyroid hormone (PTH) have been studied in a patient with hypomagnesemia and hypocalcemia following intestinal bypass surgery for obesity. When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium def...
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| Veröffentlicht in: | Journal of endocrinological investigation 1979-07, Vol.2 (3), p.267-270 |
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| container_title | Journal of endocrinological investigation |
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| creator | Nair, K S Holdaway, I M Evans, M C Cameron, A D |
| description | The interactions of serum levels of magnesium and parathyroid hormone (PTH) have been studied in a patient with hypomagnesemia and hypocalcemia following intestinal bypass surgery for obesity. When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium deficiency hypocalcemia was associated with elevation of serum PTH levels. Infusion of exogenous PTH induced a clearly detectable renal response in the presence of hypomagnesemia but the response was diminished when serum magnesium was elevated. In this patient it appears that hypomagnesemia suppressed parathyroid gland activity, leaving the renal action of PTH intact. |
| doi_str_mv | 10.1007/BF03350414 |
| format | Article |
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When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium deficiency hypocalcemia was associated with elevation of serum PTH levels. Infusion of exogenous PTH induced a clearly detectable renal response in the presence of hypomagnesemia but the response was diminished when serum magnesium was elevated. 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When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium deficiency hypocalcemia was associated with elevation of serum PTH levels. Infusion of exogenous PTH induced a clearly detectable renal response in the presence of hypomagnesemia but the response was diminished when serum magnesium was elevated. In this patient it appears that hypomagnesemia suppressed parathyroid gland activity, leaving the renal action of PTH intact.</description><subject>Calcium - blood</subject><subject>Cyclic AMP - blood</subject><subject>Cyclic AMP - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hypocalcemia - blood</subject><subject>Magnesium - blood</subject><subject>Magnesium - therapeutic use</subject><subject>Middle Aged</subject><subject>Parathyroid Hormone - blood</subject><subject>Phosphates - metabolism</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkL9PwzAQhS3Er1JYmBkyMSAFzj43dkZaUahUiQXmyLEvNCiJi50M_e8JtILp3kmfnvQ-xq453HMA9TBfAuIMJJdHbMKVgFSjzo7ZBDDnqYRcnbOLGD8BUKFWZ-xUIIcMJ2y16qpmoM5S4qukNR8dxXpoE98l_YaSSDZQX4-f6Vxi7G8cwa0Jpt_sgq9dsvGh9R1dspPKNJGuDnfK3pdPb4uXdP36vFo8rlMrNO9TLQTIcsalyzOZATpUTlmhXIbOziyV4CqluJWGkyDUVCrhtDSKG3SQc5yy233vNvivgWJftHW01DSmIz_EQsl8XJnrEbzbgzb4GANVxTbUrQm7gkPxo6341zbCN4fWoWzJ_aF7T_gNUNpmpQ</recordid><startdate>197907</startdate><enddate>197907</enddate><creator>Nair, K S</creator><creator>Holdaway, I M</creator><creator>Evans, M C</creator><creator>Cameron, A D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197907</creationdate><title>Influence of magnesium on the secretion and action of parathyroid hormone</title><author>Nair, K S ; Holdaway, I M ; Evans, M C ; Cameron, A D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-82204b514d964603d37d7c27d63dc5ceb0df771c4a1e2e38eb72d84a71a3d0913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Calcium - blood</topic><topic>Cyclic AMP - blood</topic><topic>Cyclic AMP - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hypocalcemia - blood</topic><topic>Magnesium - blood</topic><topic>Magnesium - therapeutic use</topic><topic>Middle Aged</topic><topic>Parathyroid Hormone - blood</topic><topic>Phosphates - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nair, K S</creatorcontrib><creatorcontrib>Holdaway, I M</creatorcontrib><creatorcontrib>Evans, M C</creatorcontrib><creatorcontrib>Cameron, A D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nair, K S</au><au>Holdaway, I M</au><au>Evans, M C</au><au>Cameron, A D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of magnesium on the secretion and action of parathyroid hormone</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>1979-07</date><risdate>1979</risdate><volume>2</volume><issue>3</issue><spage>267</spage><epage>270</epage><pages>267-270</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>The interactions of serum levels of magnesium and parathyroid hormone (PTH) have been studied in a patient with hypomagnesemia and hypocalcemia following intestinal bypass surgery for obesity. When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium deficiency hypocalcemia was associated with elevation of serum PTH levels. Infusion of exogenous PTH induced a clearly detectable renal response in the presence of hypomagnesemia but the response was diminished when serum magnesium was elevated. In this patient it appears that hypomagnesemia suppressed parathyroid gland activity, leaving the renal action of PTH intact.</abstract><cop>Italy</cop><pmid>231063</pmid><doi>10.1007/BF03350414</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0391-4097 |
| ispartof | Journal of endocrinological investigation, 1979-07, Vol.2 (3), p.267-270 |
| issn | 0391-4097 1720-8386 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74903798 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Calcium - blood Cyclic AMP - blood Cyclic AMP - urine Female Humans Hypocalcemia - blood Magnesium - blood Magnesium - therapeutic use Middle Aged Parathyroid Hormone - blood Phosphates - metabolism |
| title | Influence of magnesium on the secretion and action of parathyroid hormone |
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