Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Intervention: A Prospective Randomized Trial: Five-Year Results of the IMPORTANT Study
Background: Acute efficacy and long-term prognostic differences between ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (primary PCI) and those treated with pre-intervention thrombolysis combined with back-up of facilitated PCI has not been...
Gespeichert in:
| Veröffentlicht in: | Circulation Journal 2010, Vol.74(8), pp.1625-1634 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1634 |
|---|---|
| container_issue | 8 |
| container_start_page | 1625 |
| container_title | Circulation Journal |
| container_volume | 74 |
| creator | Itoh, Tomonori Fukami, Ken'ichi Suzuki, Tomomi Kimura, Takumi Kanaya, Yoshinori Orii, Makoto Goto, Iwao Matsui, Hiroki Sugawara, Shoma Nakajima, Satoshi Fusazaki, Tetsuya Nakamura, Motoyuki investigators, for the IMPORTANT |
| description | Background: Acute efficacy and long-term prognostic differences between ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (primary PCI) and those treated with pre-intervention thrombolysis combined with back-up of facilitated PCI has not been evaluated in Japanese patients. The purpose of the present study was therefore to evaluate the differences between treatment with primary PCI (primary-PCI group) and pre-treatment with tissue-type plasminogen activator (t-PA) combined with back-up of facilitated PCI (prior-t-PA group). Methods and Results: One hundred and one patients with STEMI were randomly assigned to 2 groups. Patients in the prior-t-PA group were then divided into 2 further groups, the facilitated-PCI and prior-t-PA alone groups. The patency rate at initial angiography, left ventricular ejection fraction (LVEF) at 6 months, and the major adverse cardiac event (MACE)-free rate at 5 years were then compared between the groups. The patency rate and LVEF in the prior-t-PA group was significantly higher than in the primary-PCI group (69% vs 17% respectively, P |
| doi_str_mv | 10.1253/circj.CJ-09-0873 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_749028883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>749028883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-7b8b920e5b759d0d509fc9d8a2ad0dea47c897a8b00cc15fc151a4f6b42d16a33</originalsourceid><addsrcrecordid>eNpNkU1vGyEQhlHVqPlo7z1V3HoiZVnWQG_pykkTWWpVuWfEsrMO1i64sHaU_I_-37K2k_QADJrnfQdmEPpY0MuCVeUX66JdX9Z3hCpCpSjfoLOi5IJwyejbfTwjSvLyFJ2ntKaUKVqpd-iU0UoUjKsz9LcOw8ZEl4LHocOL4FdkCXHAP2NY-ZBGZ_F8Z_qtGV1GvsH4AOBzFsitHyHuwO8Ty_sYhib0j8klbHybCTeY-IjrEIOfgv_xr_hqKpA2YEe3A_wrK8LgnqDFy-hM_x6ddKZP8OF4XqDf1_Nl_Z0sftzc1lcLYrkqRyIa2ShGoWpEpVraVlR1VrXSMJNvYLiwUgkjG0qtLaour8LwbtZw1hYzU5YX6PPBdxPDny2kUQ8uWeh74yFskxZcUSalnEh6IG1-dorQ6c3hg7qgepqF3s9C13eaKj3NIks-Hc23zQDti-C5-Rm4PgDrNJoVvAAm5q73cHQUXMtpe3V-Be5N1ODLf5jko64</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>749028883</pqid></control><display><type>article</type><title>Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Intervention: A Prospective Randomized Trial: Five-Year Results of the IMPORTANT Study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>Itoh, Tomonori ; Fukami, Ken'ichi ; Suzuki, Tomomi ; Kimura, Takumi ; Kanaya, Yoshinori ; Orii, Makoto ; Goto, Iwao ; Matsui, Hiroki ; Sugawara, Shoma ; Nakajima, Satoshi ; Fusazaki, Tetsuya ; Nakamura, Motoyuki ; investigators, for the IMPORTANT</creator><creatorcontrib>Itoh, Tomonori ; Fukami, Ken'ichi ; Suzuki, Tomomi ; Kimura, Takumi ; Kanaya, Yoshinori ; Orii, Makoto ; Goto, Iwao ; Matsui, Hiroki ; Sugawara, Shoma ; Nakajima, Satoshi ; Fusazaki, Tetsuya ; Nakamura, Motoyuki ; investigators, for the IMPORTANT ; IMPORTANT investigators</creatorcontrib><description>Background: Acute efficacy and long-term prognostic differences between ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (primary PCI) and those treated with pre-intervention thrombolysis combined with back-up of facilitated PCI has not been evaluated in Japanese patients. The purpose of the present study was therefore to evaluate the differences between treatment with primary PCI (primary-PCI group) and pre-treatment with tissue-type plasminogen activator (t-PA) combined with back-up of facilitated PCI (prior-t-PA group). Methods and Results: One hundred and one patients with STEMI were randomly assigned to 2 groups. Patients in the prior-t-PA group were then divided into 2 further groups, the facilitated-PCI and prior-t-PA alone groups. The patency rate at initial angiography, left ventricular ejection fraction (LVEF) at 6 months, and the major adverse cardiac event (MACE)-free rate at 5 years were then compared between the groups. The patency rate and LVEF in the prior-t-PA group was significantly higher than in the primary-PCI group (69% vs 17% respectively, P<0.001; 61.6±9.5% vs 55.0±11.6%, respectively; P=0.01). The MACE-free rate in the prior-t-PA group, however, was lower than in the primary-PCI group (58.7% vs 80.9%; P=0.03). The MACE-free rate in the facilitated-PCI group was equal to that in the primary-PCI group (73.7% vs 80.9%; P=0.39), whereas the MACE-free rate in the prior-t-PA-alone group was significantly lower than in the primary-PCI group (48.1% vs 80.9%; P=0.01). Conclusions: Primary PCI is superior to pre-intervention thrombolysis for long-term prognosis. Moreover, facilitated PCI may be as effective as primary PCI in patients with STEMI. (Circ J 2010; 74: 1625 - 1635)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-09-0873</identifier><identifier>PMID: 20571249</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Acute myocardial infarction ; Aged ; Angioplasty, Balloon, Coronary - methods ; Coronary Angiography ; Disease-Free Survival ; Humans ; Middle Aged ; Percutaneous coronary intervention ; Prognosis ; Reperfusion ; Stroke Volume ; Thrombolysis ; Thrombolytic Therapy - methods ; Time Factors ; Tissue Plasminogen Activator - administration & dosage ; Treatment Outcome</subject><ispartof>Circulation Journal, 2010, Vol.74(8), pp.1625-1634</ispartof><rights>2010 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-7b8b920e5b759d0d509fc9d8a2ad0dea47c897a8b00cc15fc151a4f6b42d16a33</citedby><cites>FETCH-LOGICAL-c493t-7b8b920e5b759d0d509fc9d8a2ad0dea47c897a8b00cc15fc151a4f6b42d16a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20571249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itoh, Tomonori</creatorcontrib><creatorcontrib>Fukami, Ken'ichi</creatorcontrib><creatorcontrib>Suzuki, Tomomi</creatorcontrib><creatorcontrib>Kimura, Takumi</creatorcontrib><creatorcontrib>Kanaya, Yoshinori</creatorcontrib><creatorcontrib>Orii, Makoto</creatorcontrib><creatorcontrib>Goto, Iwao</creatorcontrib><creatorcontrib>Matsui, Hiroki</creatorcontrib><creatorcontrib>Sugawara, Shoma</creatorcontrib><creatorcontrib>Nakajima, Satoshi</creatorcontrib><creatorcontrib>Fusazaki, Tetsuya</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>investigators, for the IMPORTANT</creatorcontrib><creatorcontrib>IMPORTANT investigators</creatorcontrib><title>Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Intervention: A Prospective Randomized Trial: Five-Year Results of the IMPORTANT Study</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Acute efficacy and long-term prognostic differences between ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (primary PCI) and those treated with pre-intervention thrombolysis combined with back-up of facilitated PCI has not been evaluated in Japanese patients. The purpose of the present study was therefore to evaluate the differences between treatment with primary PCI (primary-PCI group) and pre-treatment with tissue-type plasminogen activator (t-PA) combined with back-up of facilitated PCI (prior-t-PA group). Methods and Results: One hundred and one patients with STEMI were randomly assigned to 2 groups. Patients in the prior-t-PA group were then divided into 2 further groups, the facilitated-PCI and prior-t-PA alone groups. The patency rate at initial angiography, left ventricular ejection fraction (LVEF) at 6 months, and the major adverse cardiac event (MACE)-free rate at 5 years were then compared between the groups. The patency rate and LVEF in the prior-t-PA group was significantly higher than in the primary-PCI group (69% vs 17% respectively, P<0.001; 61.6±9.5% vs 55.0±11.6%, respectively; P=0.01). The MACE-free rate in the prior-t-PA group, however, was lower than in the primary-PCI group (58.7% vs 80.9%; P=0.03). The MACE-free rate in the facilitated-PCI group was equal to that in the primary-PCI group (73.7% vs 80.9%; P=0.39), whereas the MACE-free rate in the prior-t-PA-alone group was significantly lower than in the primary-PCI group (48.1% vs 80.9%; P=0.01). Conclusions: Primary PCI is superior to pre-intervention thrombolysis for long-term prognosis. Moreover, facilitated PCI may be as effective as primary PCI in patients with STEMI. (Circ J 2010; 74: 1625 - 1635)</description><subject>Acute myocardial infarction</subject><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Coronary Angiography</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Percutaneous coronary intervention</subject><subject>Prognosis</subject><subject>Reperfusion</subject><subject>Stroke Volume</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy - methods</subject><subject>Time Factors</subject><subject>Tissue Plasminogen Activator - administration & dosage</subject><subject>Treatment Outcome</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU1vGyEQhlHVqPlo7z1V3HoiZVnWQG_pykkTWWpVuWfEsrMO1i64sHaU_I_-37K2k_QADJrnfQdmEPpY0MuCVeUX66JdX9Z3hCpCpSjfoLOi5IJwyejbfTwjSvLyFJ2ntKaUKVqpd-iU0UoUjKsz9LcOw8ZEl4LHocOL4FdkCXHAP2NY-ZBGZ_F8Z_qtGV1GvsH4AOBzFsitHyHuwO8Ty_sYhib0j8klbHybCTeY-IjrEIOfgv_xr_hqKpA2YEe3A_wrK8LgnqDFy-hM_x6ddKZP8OF4XqDf1_Nl_Z0sftzc1lcLYrkqRyIa2ShGoWpEpVraVlR1VrXSMJNvYLiwUgkjG0qtLaour8LwbtZw1hYzU5YX6PPBdxPDny2kUQ8uWeh74yFskxZcUSalnEh6IG1-dorQ6c3hg7qgepqF3s9C13eaKj3NIks-Hc23zQDti-C5-Rm4PgDrNJoVvAAm5q73cHQUXMtpe3V-Be5N1ODLf5jko64</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Itoh, Tomonori</creator><creator>Fukami, Ken'ichi</creator><creator>Suzuki, Tomomi</creator><creator>Kimura, Takumi</creator><creator>Kanaya, Yoshinori</creator><creator>Orii, Makoto</creator><creator>Goto, Iwao</creator><creator>Matsui, Hiroki</creator><creator>Sugawara, Shoma</creator><creator>Nakajima, Satoshi</creator><creator>Fusazaki, Tetsuya</creator><creator>Nakamura, Motoyuki</creator><creator>investigators, for the IMPORTANT</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Intervention: A Prospective Randomized Trial</title><author>Itoh, Tomonori ; Fukami, Ken'ichi ; Suzuki, Tomomi ; Kimura, Takumi ; Kanaya, Yoshinori ; Orii, Makoto ; Goto, Iwao ; Matsui, Hiroki ; Sugawara, Shoma ; Nakajima, Satoshi ; Fusazaki, Tetsuya ; Nakamura, Motoyuki ; investigators, for the IMPORTANT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-7b8b920e5b759d0d509fc9d8a2ad0dea47c897a8b00cc15fc151a4f6b42d16a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute myocardial infarction</topic><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Coronary Angiography</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Percutaneous coronary intervention</topic><topic>Prognosis</topic><topic>Reperfusion</topic><topic>Stroke Volume</topic><topic>Thrombolysis</topic><topic>Thrombolytic Therapy - methods</topic><topic>Time Factors</topic><topic>Tissue Plasminogen Activator - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Itoh, Tomonori</creatorcontrib><creatorcontrib>Fukami, Ken'ichi</creatorcontrib><creatorcontrib>Suzuki, Tomomi</creatorcontrib><creatorcontrib>Kimura, Takumi</creatorcontrib><creatorcontrib>Kanaya, Yoshinori</creatorcontrib><creatorcontrib>Orii, Makoto</creatorcontrib><creatorcontrib>Goto, Iwao</creatorcontrib><creatorcontrib>Matsui, Hiroki</creatorcontrib><creatorcontrib>Sugawara, Shoma</creatorcontrib><creatorcontrib>Nakajima, Satoshi</creatorcontrib><creatorcontrib>Fusazaki, Tetsuya</creatorcontrib><creatorcontrib>Nakamura, Motoyuki</creatorcontrib><creatorcontrib>investigators, for the IMPORTANT</creatorcontrib><creatorcontrib>IMPORTANT investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Itoh, Tomonori</au><au>Fukami, Ken'ichi</au><au>Suzuki, Tomomi</au><au>Kimura, Takumi</au><au>Kanaya, Yoshinori</au><au>Orii, Makoto</au><au>Goto, Iwao</au><au>Matsui, Hiroki</au><au>Sugawara, Shoma</au><au>Nakajima, Satoshi</au><au>Fusazaki, Tetsuya</au><au>Nakamura, Motoyuki</au><au>investigators, for the IMPORTANT</au><aucorp>IMPORTANT investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Intervention: A Prospective Randomized Trial: Five-Year Results of the IMPORTANT Study</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2010</date><risdate>2010</risdate><volume>74</volume><issue>8</issue><spage>1625</spage><epage>1634</epage><pages>1625-1634</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: Acute efficacy and long-term prognostic differences between ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (primary PCI) and those treated with pre-intervention thrombolysis combined with back-up of facilitated PCI has not been evaluated in Japanese patients. The purpose of the present study was therefore to evaluate the differences between treatment with primary PCI (primary-PCI group) and pre-treatment with tissue-type plasminogen activator (t-PA) combined with back-up of facilitated PCI (prior-t-PA group). Methods and Results: One hundred and one patients with STEMI were randomly assigned to 2 groups. Patients in the prior-t-PA group were then divided into 2 further groups, the facilitated-PCI and prior-t-PA alone groups. The patency rate at initial angiography, left ventricular ejection fraction (LVEF) at 6 months, and the major adverse cardiac event (MACE)-free rate at 5 years were then compared between the groups. The patency rate and LVEF in the prior-t-PA group was significantly higher than in the primary-PCI group (69% vs 17% respectively, P<0.001; 61.6±9.5% vs 55.0±11.6%, respectively; P=0.01). The MACE-free rate in the prior-t-PA group, however, was lower than in the primary-PCI group (58.7% vs 80.9%; P=0.03). The MACE-free rate in the facilitated-PCI group was equal to that in the primary-PCI group (73.7% vs 80.9%; P=0.39), whereas the MACE-free rate in the prior-t-PA-alone group was significantly lower than in the primary-PCI group (48.1% vs 80.9%; P=0.01). Conclusions: Primary PCI is superior to pre-intervention thrombolysis for long-term prognosis. Moreover, facilitated PCI may be as effective as primary PCI in patients with STEMI. (Circ J 2010; 74: 1625 - 1635)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>20571249</pmid><doi>10.1253/circj.CJ-09-0873</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-9843 |
| ispartof | Circulation Journal, 2010, Vol.74(8), pp.1625-1634 |
| issn | 1346-9843 1347-4820 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_749028883 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Acute myocardial infarction Aged Angioplasty, Balloon, Coronary - methods Coronary Angiography Disease-Free Survival Humans Middle Aged Percutaneous coronary intervention Prognosis Reperfusion Stroke Volume Thrombolysis Thrombolytic Therapy - methods Time Factors Tissue Plasminogen Activator - administration & dosage Treatment Outcome |
| title | Comparison of Long-Term Prognostic Evaluation Between Pre-Intervention Thrombolysis and Primary Coronary Intervention: A Prospective Randomized Trial: Five-Year Results of the IMPORTANT Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T16%3A19%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20Long-Term%20Prognostic%20Evaluation%20Between%20Pre-Intervention%20Thrombolysis%20and%20Primary%20Coronary%20Intervention:%20A%20Prospective%20Randomized%20Trial:%20Five-Year%20Results%20of%20the%20IMPORTANT%20Study&rft.jtitle=Circulation%20Journal&rft.au=Itoh,%20Tomonori&rft.aucorp=IMPORTANT%20investigators&rft.date=2010&rft.volume=74&rft.issue=8&rft.spage=1625&rft.epage=1634&rft.pages=1625-1634&rft.issn=1346-9843&rft.eissn=1347-4820&rft_id=info:doi/10.1253/circj.CJ-09-0873&rft_dat=%3Cproquest_cross%3E749028883%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=749028883&rft_id=info:pmid/20571249&rfr_iscdi=true |