Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1

BackgroundLIM and SH3 protein 1 (LASP-1), initially identified from a cDNA library of metastatic axillary lymph nodes of breast cancer patients, is a specific focal adhesion protein involved in numerous biological and pathological processes. The overexpression of LASP-1 has been described in several...

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Veröffentlicht in:	Gut 2010-09, Vol.59 (9), p.1226-1235
Hauptverfasser:	Zhao, Liang, Wang, Hui, Liu, Chao, Liu, Yawei, Wang, Xiaoyan, Wang, Shuang, Sun, Xuegang, Li, Jianming, Deng, Yongjian, Jiang, Yong, Ding, Yanqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Animals Biological and medical sciences Breast cancer Cell growth Cell Movement - physiology Cell Proliferation Colorectal cancer colorectal carcinoma colorectal neogenesis Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - physiology Disease Progression Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques - methods Humans Kinases LIM and SH3 protein 1 LIM Domain Proteins Lymphatic system Medical prognosis Medical sciences Metastasis Mice Mice, Nude Neoplasm Metastasis - physiopathology Neoplasm Proteins - physiology Neoplasm Transplantation Ovarian cancer Pathogenesis Phenotype poor prognosis Prognosis Protein expression Proteins proteomics RNA, Messenger - genetics RNA, Neoplasm - genetics Signal transduction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Cells, Cultured Tumors tumour metastasis
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