Microbial paclitaxel: advances and perspectives
Paclitaxel is a potent and widely used antitumor agent. Considerable worldwide research efforts have been carried out on different production alternatives. Since the description of the first paclitaxel-producing fungi, more than 15 years ago, microorganisms have been investigated as potential altern...
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| Veröffentlicht in: | Journal of antibiotics 2010-08, Vol.63 (8), p.460-467 |
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| creator | Flores-Bustamante, Zoila R Rivera-Orduña, Flor N Martínez-Cárdenas, Anahí Flores-Cotera, Luis B |
| description | Paclitaxel is a potent and widely used antitumor agent. Considerable worldwide research efforts have been carried out on different production alternatives. Since the description of the first paclitaxel-producing fungi, more than 15 years ago, microorganisms have been investigated as potential alternatives for an environmentally acceptable, relatively simple and inexpensive method to produce paclitaxel. However, in spite of significant research on paclitaxel-producing microorganisms, no commercial fermentation process has been implemented up to now. The aim of this study is to review the present status of research on paclitaxel-producing microorganisms and the ongoing efforts to develop heterologous paclitaxel biosynthesis, and analyze the perspectives of microbial fermentation for paclitaxel production. |
| doi_str_mv | 10.1038/ja.2010.83 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 631/326/252 631/326/325 631/92/60 Amino Acid Sequence Antineoplastic Agents - metabolism Bacteria - metabolism Bacteriology Biomedical and Life Sciences Biomedical Research - trends Bioorganic Chemistry Biosynthesis Biotechnology - trends Fermentation Fungi - metabolism Humans Life Sciences Medicinal Chemistry Microbiology Microorganisms Molecular Sequence Data Organic Chemistry Paclitaxel - biosynthesis review-article |
| title | Microbial paclitaxel: advances and perspectives |
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