One-step preparation of chitosan solid nanoparticles by electrospray deposition
Solid micro- and nanoparticles were prepared from chitosan/acetic acid solution in one-step by the electrospray procedure. The effects of various solution properties and processing parameters on particle formation were investigated. Solution viscosity and conductivity were the most important factors...
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| Veröffentlicht in: | International journal of pharmaceutics 2010-09, Vol.397 (1), p.211-217 |
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| container_title | International journal of pharmaceutics |
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| creator | Zhang, Shaoling Kawakami, Kohsaku |
| description | Solid micro- and nanoparticles were prepared from chitosan/acetic acid solution in one-step by the electrospray procedure. The effects of various solution properties and processing parameters on particle formation were investigated. Solution viscosity and conductivity were the most important factors affecting electrospray behavior, i.e., stable electrospray was achieved only when viscosity was high and/or conductivity was low. Smaller particles could be obtained by decreasing acetic acid concentration, chitosan concentration, and/or flow rate. Furthermore, addition of ethanol could effectively stabilize the electrospray by decreasing the solution conductivity and increasing the solution viscosity. By optimizing the solution and operation parameters, the average diameter of the chitosan particles was reduced down to 124
nm, suggesting that electrospray is promising in producing solid micro- and nanoparticles for oral and pulmonary drug delivery systems. |
| doi_str_mv | 10.1016/j.ijpharm.2010.07.007 |
| format | Article |
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nm, suggesting that electrospray is promising in producing solid micro- and nanoparticles for oral and pulmonary drug delivery systems.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2010.07.007</identifier><identifier>PMID: 20637272</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acetic Acid - chemistry ; Biological and medical sciences ; Chitosan ; Chitosan - chemistry ; Dosage Forms ; Drug Carriers ; Drug Delivery Systems ; Electrospray deposition ; Ethanol - chemistry ; General pharmacology ; Hexanols - chemistry ; Medical sciences ; Nanoparticle ; Nanoparticles ; Nanotechnology ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Solutions ; Surface Properties ; Viscosity</subject><ispartof>International journal of pharmaceutics, 2010-09, Vol.397 (1), p.211-217</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-2b08839fb1d99ac1c057a46498c11cedfdb90a289a2e3279fadab5a4b1e14d3f3</citedby><cites>FETCH-LOGICAL-c460t-2b08839fb1d99ac1c057a46498c11cedfdb90a289a2e3279fadab5a4b1e14d3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037851731000517X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23204101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20637272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Shaoling</creatorcontrib><creatorcontrib>Kawakami, Kohsaku</creatorcontrib><title>One-step preparation of chitosan solid nanoparticles by electrospray deposition</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Solid micro- and nanoparticles were prepared from chitosan/acetic acid solution in one-step by the electrospray procedure. The effects of various solution properties and processing parameters on particle formation were investigated. Solution viscosity and conductivity were the most important factors affecting electrospray behavior, i.e., stable electrospray was achieved only when viscosity was high and/or conductivity was low. Smaller particles could be obtained by decreasing acetic acid concentration, chitosan concentration, and/or flow rate. Furthermore, addition of ethanol could effectively stabilize the electrospray by decreasing the solution conductivity and increasing the solution viscosity. By optimizing the solution and operation parameters, the average diameter of the chitosan particles was reduced down to 124
nm, suggesting that electrospray is promising in producing solid micro- and nanoparticles for oral and pulmonary drug delivery systems.</description><subject>Acetic Acid - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Dosage Forms</subject><subject>Drug Carriers</subject><subject>Drug Delivery Systems</subject><subject>Electrospray deposition</subject><subject>Ethanol - chemistry</subject><subject>General pharmacology</subject><subject>Hexanols - chemistry</subject><subject>Medical sciences</subject><subject>Nanoparticle</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Solutions</subject><subject>Surface Properties</subject><subject>Viscosity</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P4zAQhq0VK1pYfsKiXNCeUsZ2EicnhCoWkJB62T1bE3uiukrjYKdI_fe4aoEjJ0vj552Ph7HfHBYceHW7WbjNuMawXQhINVALAPWDzXmtZC4LVZ2xOUhV5yVXcsYuYtwAQCW4PGczAZVUQok5W60GyuNEYzYGGjHg5PyQ-S4zazf5iEMWfe9sNuDg0_fkTE8xa_cZ9WSm4OMYcJ9ZGn10h-gv9rPDPtLV6b1k__8-_Fs-5S-rx-fl_UtuigqmXLRQ17LpWm6bBg03UCosqqKpDeeGbGfbBlDUDQqSQjUdWmxLLFpOvLCyk5fsz7HvGPzrjuKkty4a6nscyO-iVkUDQpacJ7I8kiZtGwN1egxui2GvOeiDSr3RJ5X6oFKD0kllyl2fJuzaLdnP1Ie7BNycAIwG-y7gYFz84qSAIvVP3N2Ro-TjzVHQ0Tga0pUuJIfaevfNKu865ZYv</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Zhang, Shaoling</creator><creator>Kawakami, Kohsaku</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100915</creationdate><title>One-step preparation of chitosan solid nanoparticles by electrospray deposition</title><author>Zhang, Shaoling ; Kawakami, Kohsaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-2b08839fb1d99ac1c057a46498c11cedfdb90a289a2e3279fadab5a4b1e14d3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acetic Acid - chemistry</topic><topic>Biological and medical sciences</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>Dosage Forms</topic><topic>Drug Carriers</topic><topic>Drug Delivery Systems</topic><topic>Electrospray deposition</topic><topic>Ethanol - chemistry</topic><topic>General pharmacology</topic><topic>Hexanols - chemistry</topic><topic>Medical sciences</topic><topic>Nanoparticle</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Solutions</topic><topic>Surface Properties</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shaoling</creatorcontrib><creatorcontrib>Kawakami, Kohsaku</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shaoling</au><au>Kawakami, Kohsaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-step preparation of chitosan solid nanoparticles by electrospray deposition</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2010-09-15</date><risdate>2010</risdate><volume>397</volume><issue>1</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Solid micro- and nanoparticles were prepared from chitosan/acetic acid solution in one-step by the electrospray procedure. The effects of various solution properties and processing parameters on particle formation were investigated. Solution viscosity and conductivity were the most important factors affecting electrospray behavior, i.e., stable electrospray was achieved only when viscosity was high and/or conductivity was low. Smaller particles could be obtained by decreasing acetic acid concentration, chitosan concentration, and/or flow rate. Furthermore, addition of ethanol could effectively stabilize the electrospray by decreasing the solution conductivity and increasing the solution viscosity. By optimizing the solution and operation parameters, the average diameter of the chitosan particles was reduced down to 124
nm, suggesting that electrospray is promising in producing solid micro- and nanoparticles for oral and pulmonary drug delivery systems.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20637272</pmid><doi>10.1016/j.ijpharm.2010.07.007</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2010-09, Vol.397 (1), p.211-217 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acetic Acid - chemistry Biological and medical sciences Chitosan Chitosan - chemistry Dosage Forms Drug Carriers Drug Delivery Systems Electrospray deposition Ethanol - chemistry General pharmacology Hexanols - chemistry Medical sciences Nanoparticle Nanoparticles Nanotechnology Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solutions Surface Properties Viscosity |
| title | One-step preparation of chitosan solid nanoparticles by electrospray deposition |
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