Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation

Diosgenin is a precursor of steroid hormones, which can be found in several plant species. Diosgenin has been shown to have a variety of biological activities including anti-inflammatory activity, but through a mechanism that is unclear. Especially, the effect of this agent on macrophage function ha...

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Veröffentlicht in:	International immunopharmacology 2010-09, Vol.10 (9), p.1047-1054
Hauptverfasser:	Jung, Da-Hye, Park, Hye-Jin, Byun, Hye-Eun, Park, Yoon-Moon, Kim, Tae-Wan, Kim, Byung-Oh, Um, Sung-Hee, Pyo, Suhkneung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Casein Kinase II - analysis Casein Kinase II - antagonists & inhibitors Cell Culture Techniques Diosgenin - pharmacology Down-Regulation Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Interferon-gamma - pharmacology Interleukin-1 - analysis Interleukin-6 - analysis JNK Mitogen-Activated Protein Kinases - analysis JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors Lipopolysaccharides - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - enzymology Male Mice NF-kappa B - analysis NF-kappa B - antagonists & inhibitors Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - analysis Reactive Oxygen Species - analysis Reactive Oxygen Species - metabolism Transcription Factor AP-1 - analysis Transcription Factor AP-1 - antagonists & inhibitors Transcription, Genetic - drug effects
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