A prospective randomized comparison of nebulized morphine versus thoracic epidural analgesia in the management of thoracic trauma
Successful management of pain reduces morbidity and improves patient satisfaction of patient after a chest trauma. The purpose of the study was to evaluate the efficacy of the respiratory administration of nebulized morphine in such patients. Patients were included in this prospective and randomized...
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| Veröffentlicht in: | Annales françaises d'anesthésie et de réanimation 2010-06, Vol.29 (6), p.415-418 |
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| container_title | Annales françaises d'anesthésie et de réanimation |
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| creator | Nejmi, H Fath, K Anaflous, R Sourour, S Samkaoui, M A |
| description | Successful management of pain reduces morbidity and improves patient satisfaction of patient after a chest trauma. The purpose of the study was to evaluate the efficacy of the respiratory administration of nebulized morphine in such patients.
Patients were included in this prospective and randomized study patients to receive either nebulized morphine in group M or a mixture of bupivacaine-fentanyl by epidural route. In group M, patients received nebulized morphine every 30 minutes until the second hour then every 4 hours during 48 hours. In the thoracic epidural analgesia group (group P) they received a mixture of 0.125% bupivacaine and 0.115% of fentanyl continuously infused at the rate of 7 ml/h during 48 hours. The main criterion of judgment was the analgesic effects of analgesic regimen with EVA < 4. Sedation, haemodynamic and respiratory parameters were continuously recorded, as adverse side effects were they occurred. Statistical comparisons were performed with Chi(2), Fisher or Student t-test when appropriate (p |
| doi_str_mv | 10.1016/j.annfar.2010.02.026 |
| format | Article |
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Patients were included in this prospective and randomized study patients to receive either nebulized morphine in group M or a mixture of bupivacaine-fentanyl by epidural route. In group M, patients received nebulized morphine every 30 minutes until the second hour then every 4 hours during 48 hours. In the thoracic epidural analgesia group (group P) they received a mixture of 0.125% bupivacaine and 0.115% of fentanyl continuously infused at the rate of 7 ml/h during 48 hours. The main criterion of judgment was the analgesic effects of analgesic regimen with EVA < 4. Sedation, haemodynamic and respiratory parameters were continuously recorded, as adverse side effects were they occurred. Statistical comparisons were performed with Chi(2), Fisher or Student t-test when appropriate (p<0.05).
Forty patients were randomized in two groups. Groups were not different regarding the demographic parameters. Analgesia was effective in both groups (NS). Sedation, hemodynamic and respiratory parameters were not different between groups. No side effect was noted in groups.
Nebulized morphine was an analgesic technique as effective as epidural bupivacaine-fentanyl in our series. This non-invasive route of administration of morphine appears to be useful to treat pain after a chest trauma.</description><identifier>EISSN: 1769-6623</identifier><identifier>DOI: 10.1016/j.annfar.2010.02.026</identifier><identifier>PMID: 20537851</identifier><language>fre</language><publisher>France</publisher><subject>Adult ; Analgesia, Epidural ; Analgesics, Opioid - administration & dosage ; Anesthetics, Local - administration & dosage ; Bupivacaine - administration & dosage ; Female ; Fentanyl - administration & dosage ; Humans ; Male ; Morphine - administration & dosage ; Nebulizers and Vaporizers ; Pain - etiology ; Pain Management ; Prospective Studies ; Thoracic Injuries - complications</subject><ispartof>Annales françaises d'anesthésie et de réanimation, 2010-06, Vol.29 (6), p.415-418</ispartof><rights>2010 Elsevier Masson SAS. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20537851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nejmi, H</creatorcontrib><creatorcontrib>Fath, K</creatorcontrib><creatorcontrib>Anaflous, R</creatorcontrib><creatorcontrib>Sourour, S</creatorcontrib><creatorcontrib>Samkaoui, M A</creatorcontrib><title>A prospective randomized comparison of nebulized morphine versus thoracic epidural analgesia in the management of thoracic trauma</title><title>Annales françaises d'anesthésie et de réanimation</title><addtitle>Ann Fr Anesth Reanim</addtitle><description>Successful management of pain reduces morbidity and improves patient satisfaction of patient after a chest trauma. The purpose of the study was to evaluate the efficacy of the respiratory administration of nebulized morphine in such patients.
Patients were included in this prospective and randomized study patients to receive either nebulized morphine in group M or a mixture of bupivacaine-fentanyl by epidural route. In group M, patients received nebulized morphine every 30 minutes until the second hour then every 4 hours during 48 hours. In the thoracic epidural analgesia group (group P) they received a mixture of 0.125% bupivacaine and 0.115% of fentanyl continuously infused at the rate of 7 ml/h during 48 hours. The main criterion of judgment was the analgesic effects of analgesic regimen with EVA < 4. Sedation, haemodynamic and respiratory parameters were continuously recorded, as adverse side effects were they occurred. Statistical comparisons were performed with Chi(2), Fisher or Student t-test when appropriate (p<0.05).
Forty patients were randomized in two groups. Groups were not different regarding the demographic parameters. Analgesia was effective in both groups (NS). Sedation, hemodynamic and respiratory parameters were not different between groups. No side effect was noted in groups.
Nebulized morphine was an analgesic technique as effective as epidural bupivacaine-fentanyl in our series. This non-invasive route of administration of morphine appears to be useful to treat pain after a chest trauma.</description><subject>Adult</subject><subject>Analgesia, Epidural</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Bupivacaine - administration & dosage</subject><subject>Female</subject><subject>Fentanyl - administration & dosage</subject><subject>Humans</subject><subject>Male</subject><subject>Morphine - administration & dosage</subject><subject>Nebulizers and Vaporizers</subject><subject>Pain - etiology</subject><subject>Pain Management</subject><subject>Prospective Studies</subject><subject>Thoracic Injuries - complications</subject><issn>1769-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UE1LAzEUDILYWv0HIrl5ak02m_04luIXFLzoeXlNXtqUTXZNdgt6858btQoP3mNm3sAMIVecLTjjxe1-Ad4bCIuMJYhlaYoTMuVlUc-LIhMTch7jnjEmRc7PyCRLR1lJPiWfS9qHLvaoBntAGsDrztkP1FR1rodgY-dpZ6jHzdj-4K4L_c56pAcMcYx02HUBlFUUe6vHAC0FD-0WowVqfaKRuoRs0aEfvq3-H4YAo4MLcmqgjXh53DPyen_3snqcr58fnlbL9XzLCzmkGAbrvIRcgUZVc20yjrkBqLQojeAF8npjpKoqhVIqVknBmJC5xk2lS0AxIze_vinv24hxaJyNCtsWPHZjbMq8ZqkwXibl9VE5bhzqpg_WQXhv_loTXzPhcwM</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Nejmi, H</creator><creator>Fath, K</creator><creator>Anaflous, R</creator><creator>Sourour, S</creator><creator>Samkaoui, M A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>A prospective randomized comparison of nebulized morphine versus thoracic epidural analgesia in the management of thoracic trauma</title><author>Nejmi, H ; Fath, K ; Anaflous, R ; Sourour, S ; Samkaoui, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g165t-66fe947a4cadec91df21e4faa8d37f316e19bf5c88ce55c085300354deb8d7ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Analgesia, Epidural</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Bupivacaine - administration & dosage</topic><topic>Female</topic><topic>Fentanyl - administration & dosage</topic><topic>Humans</topic><topic>Male</topic><topic>Morphine - administration & dosage</topic><topic>Nebulizers and Vaporizers</topic><topic>Pain - etiology</topic><topic>Pain Management</topic><topic>Prospective Studies</topic><topic>Thoracic Injuries - complications</topic><toplevel>online_resources</toplevel><creatorcontrib>Nejmi, H</creatorcontrib><creatorcontrib>Fath, K</creatorcontrib><creatorcontrib>Anaflous, R</creatorcontrib><creatorcontrib>Sourour, S</creatorcontrib><creatorcontrib>Samkaoui, M A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annales françaises d'anesthésie et de réanimation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nejmi, H</au><au>Fath, K</au><au>Anaflous, R</au><au>Sourour, S</au><au>Samkaoui, M A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective randomized comparison of nebulized morphine versus thoracic epidural analgesia in the management of thoracic trauma</atitle><jtitle>Annales françaises d'anesthésie et de réanimation</jtitle><addtitle>Ann Fr Anesth Reanim</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>29</volume><issue>6</issue><spage>415</spage><epage>418</epage><pages>415-418</pages><eissn>1769-6623</eissn><abstract>Successful management of pain reduces morbidity and improves patient satisfaction of patient after a chest trauma. The purpose of the study was to evaluate the efficacy of the respiratory administration of nebulized morphine in such patients.
Patients were included in this prospective and randomized study patients to receive either nebulized morphine in group M or a mixture of bupivacaine-fentanyl by epidural route. In group M, patients received nebulized morphine every 30 minutes until the second hour then every 4 hours during 48 hours. In the thoracic epidural analgesia group (group P) they received a mixture of 0.125% bupivacaine and 0.115% of fentanyl continuously infused at the rate of 7 ml/h during 48 hours. The main criterion of judgment was the analgesic effects of analgesic regimen with EVA < 4. Sedation, haemodynamic and respiratory parameters were continuously recorded, as adverse side effects were they occurred. Statistical comparisons were performed with Chi(2), Fisher or Student t-test when appropriate (p<0.05).
Forty patients were randomized in two groups. Groups were not different regarding the demographic parameters. Analgesia was effective in both groups (NS). Sedation, hemodynamic and respiratory parameters were not different between groups. No side effect was noted in groups.
Nebulized morphine was an analgesic technique as effective as epidural bupivacaine-fentanyl in our series. This non-invasive route of administration of morphine appears to be useful to treat pain after a chest trauma.</abstract><cop>France</cop><pmid>20537851</pmid><doi>10.1016/j.annfar.2010.02.026</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1769-6623 |
| ispartof | Annales françaises d'anesthésie et de réanimation, 2010-06, Vol.29 (6), p.415-418 |
| issn | 1769-6623 |
| language | fre |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Analgesia, Epidural Analgesics, Opioid - administration & dosage Anesthetics, Local - administration & dosage Bupivacaine - administration & dosage Female Fentanyl - administration & dosage Humans Male Morphine - administration & dosage Nebulizers and Vaporizers Pain - etiology Pain Management Prospective Studies Thoracic Injuries - complications |
| title | A prospective randomized comparison of nebulized morphine versus thoracic epidural analgesia in the management of thoracic trauma |
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