Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: safety and feasibility
Background Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods Twenty-two patien...
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| Veröffentlicht in: | Heart rhythm 2010-08, Vol.7 (8), p.1036-1042 |
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| creator | Santangeli, Pasquale Di Biase, Luigi, MD Lakkireddy, Dhanunjay, MD Burkhardt, J. David, MD Pillarisetti, Jayasree, MD Michowitz, Yoav, MD Sanchez, Javier E., MD Horton, Rodney, MD Mohanty, Prasant, MBBS, MPH Gallinghouse, G. Joseph, MD Dello Russo, Antonio, MD Casella, Michela, MD Pelargonio, Gemma, MD Santarelli, Pietro, MD Verma, Atul, MD Narasimhan, Calambur, MD Shivkumar, Kalyanam, MD Natale, Andrea, MD, FACC, FHRS |
| description | Background Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate. |
| doi_str_mv | 10.1016/j.hrthm.2010.05.022 |
| format | Article |
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David, MD ; Pillarisetti, Jayasree, MD ; Michowitz, Yoav, MD ; Sanchez, Javier E., MD ; Horton, Rodney, MD ; Mohanty, Prasant, MBBS, MPH ; Gallinghouse, G. Joseph, MD ; Dello Russo, Antonio, MD ; Casella, Michela, MD ; Pelargonio, Gemma, MD ; Santarelli, Pietro, MD ; Verma, Atul, MD ; Narasimhan, Calambur, MD ; Shivkumar, Kalyanam, MD ; Natale, Andrea, MD, FACC, FHRS</creator><creatorcontrib>Santangeli, Pasquale ; Di Biase, Luigi, MD ; Lakkireddy, Dhanunjay, MD ; Burkhardt, J. David, MD ; Pillarisetti, Jayasree, MD ; Michowitz, Yoav, MD ; Sanchez, Javier E., MD ; Horton, Rodney, MD ; Mohanty, Prasant, MBBS, MPH ; Gallinghouse, G. Joseph, MD ; Dello Russo, Antonio, MD ; Casella, Michela, MD ; Pelargonio, Gemma, MD ; Santarelli, Pietro, MD ; Verma, Atul, MD ; Narasimhan, Calambur, MD ; Shivkumar, Kalyanam, MD ; Natale, Andrea, MD, FACC, FHRS</creatorcontrib><description>Background Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.</description><identifier>ISSN: 1547-5271</identifier><identifier>EISSN: 1556-3871</identifier><identifier>DOI: 10.1016/j.hrthm.2010.05.022</identifier><identifier>PMID: 20493276</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Cardiomyopathy, Hypertrophic - complications ; Cardiovascular ; Catheter Ablation ; Female ; Humans ; Hypertrophic cardiomyopathy ; Male ; Middle Aged ; Outcomes ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - surgery ; Treatment Outcome ; Ventricular tachycardia</subject><ispartof>Heart rhythm, 2010-08, Vol.7 (8), p.1036-1042</ispartof><rights>Heart Rhythm Society</rights><rights>2010 Heart Rhythm Society</rights><rights>Copyright 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-347520c0459bab838875ade6b23669a69ee0aa7059b804f197fdcc915f85f7733</citedby><cites>FETCH-LOGICAL-c413t-347520c0459bab838875ade6b23669a69ee0aa7059b804f197fdcc915f85f7733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1547527110005059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20493276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santangeli, Pasquale</creatorcontrib><creatorcontrib>Di Biase, Luigi, MD</creatorcontrib><creatorcontrib>Lakkireddy, Dhanunjay, MD</creatorcontrib><creatorcontrib>Burkhardt, J. David, MD</creatorcontrib><creatorcontrib>Pillarisetti, Jayasree, MD</creatorcontrib><creatorcontrib>Michowitz, Yoav, MD</creatorcontrib><creatorcontrib>Sanchez, Javier E., MD</creatorcontrib><creatorcontrib>Horton, Rodney, MD</creatorcontrib><creatorcontrib>Mohanty, Prasant, MBBS, MPH</creatorcontrib><creatorcontrib>Gallinghouse, G. Joseph, MD</creatorcontrib><creatorcontrib>Dello Russo, Antonio, MD</creatorcontrib><creatorcontrib>Casella, Michela, MD</creatorcontrib><creatorcontrib>Pelargonio, Gemma, MD</creatorcontrib><creatorcontrib>Santarelli, Pietro, MD</creatorcontrib><creatorcontrib>Verma, Atul, MD</creatorcontrib><creatorcontrib>Narasimhan, Calambur, MD</creatorcontrib><creatorcontrib>Shivkumar, Kalyanam, MD</creatorcontrib><creatorcontrib>Natale, Andrea, MD, FACC, FHRS</creatorcontrib><title>Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: safety and feasibility</title><title>Heart rhythm</title><addtitle>Heart Rhythm</addtitle><description>Background Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiomyopathy, Hypertrophic - complications</subject><subject>Cardiovascular</subject><subject>Catheter Ablation</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertrophic cardiomyopathy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outcomes</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Tachycardia, Ventricular - surgery</subject><subject>Treatment Outcome</subject><subject>Ventricular tachycardia</subject><issn>1547-5271</issn><issn>1556-3871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2L1jAQxoso7of-BYLk5qmvk6RpWkFhWXQVFgQ_ziFNJzSvbVOTdKU3_3RT39WDF08JM8_zDPObonhG4UCB1i-PhyGkYTowyBUQB2DsQXFOhahL3kj6cP9XshRM0rPiIsYjAGtr4I-LMwZVy5msz4ufn3TvvA34fcXZbMToNGDCQHQ36uT8TLwldzin4Mw66lwPYdjyWKcjcTNZsih3I_nh0kCGbcGQgl8GZ3JUyNHT5rNm2F6RqC2mjei5JxZ1dJ0bXdqeFI-sHiM-vX8vi6_v3n65fl_efrz5cH11W5qK8lTySgoGBirRdrpreNNIoXusO8brutV1iwhaS8jtBipLW2l7Y1oqbCOslJxfFi9OuUvwedeY1OSiwXHUM_o1Klm1QCWvmqzkJ6UJPsaAVi3BTTpsioLayauj-k1e7eQVCJXJZ9fz-_y1m7D_6_mDOgtenwSYt7xzGFQ0GZ3B3gU0SfXe_WfAm3_8ZnSzM3r8hhvGo1_DnAEqqiJToD7vx99vTwFAZC78Fz3_rgE</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Santangeli, Pasquale</creator><creator>Di Biase, Luigi, MD</creator><creator>Lakkireddy, Dhanunjay, MD</creator><creator>Burkhardt, J. David, MD</creator><creator>Pillarisetti, Jayasree, MD</creator><creator>Michowitz, Yoav, MD</creator><creator>Sanchez, Javier E., MD</creator><creator>Horton, Rodney, MD</creator><creator>Mohanty, Prasant, MBBS, MPH</creator><creator>Gallinghouse, G. Joseph, MD</creator><creator>Dello Russo, Antonio, MD</creator><creator>Casella, Michela, MD</creator><creator>Pelargonio, Gemma, MD</creator><creator>Santarelli, Pietro, MD</creator><creator>Verma, Atul, MD</creator><creator>Narasimhan, Calambur, MD</creator><creator>Shivkumar, Kalyanam, MD</creator><creator>Natale, Andrea, MD, FACC, FHRS</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: safety and feasibility</title><author>Santangeli, Pasquale ; Di Biase, Luigi, MD ; Lakkireddy, Dhanunjay, MD ; Burkhardt, J. David, MD ; Pillarisetti, Jayasree, MD ; Michowitz, Yoav, MD ; Sanchez, Javier E., MD ; Horton, Rodney, MD ; Mohanty, Prasant, MBBS, MPH ; Gallinghouse, G. Joseph, MD ; Dello Russo, Antonio, MD ; Casella, Michela, MD ; Pelargonio, Gemma, MD ; Santarelli, Pietro, MD ; Verma, Atul, MD ; Narasimhan, Calambur, MD ; Shivkumar, Kalyanam, MD ; Natale, Andrea, MD, FACC, FHRS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-347520c0459bab838875ade6b23669a69ee0aa7059b804f197fdcc915f85f7733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardiomyopathy, Hypertrophic - complications</topic><topic>Cardiovascular</topic><topic>Catheter Ablation</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertrophic cardiomyopathy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Outcomes</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Tachycardia, Ventricular - surgery</topic><topic>Treatment Outcome</topic><topic>Ventricular tachycardia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santangeli, Pasquale</creatorcontrib><creatorcontrib>Di Biase, Luigi, MD</creatorcontrib><creatorcontrib>Lakkireddy, Dhanunjay, MD</creatorcontrib><creatorcontrib>Burkhardt, J. David, MD</creatorcontrib><creatorcontrib>Pillarisetti, Jayasree, MD</creatorcontrib><creatorcontrib>Michowitz, Yoav, MD</creatorcontrib><creatorcontrib>Sanchez, Javier E., MD</creatorcontrib><creatorcontrib>Horton, Rodney, MD</creatorcontrib><creatorcontrib>Mohanty, Prasant, MBBS, MPH</creatorcontrib><creatorcontrib>Gallinghouse, G. Joseph, MD</creatorcontrib><creatorcontrib>Dello Russo, Antonio, MD</creatorcontrib><creatorcontrib>Casella, Michela, MD</creatorcontrib><creatorcontrib>Pelargonio, Gemma, MD</creatorcontrib><creatorcontrib>Santarelli, Pietro, MD</creatorcontrib><creatorcontrib>Verma, Atul, MD</creatorcontrib><creatorcontrib>Narasimhan, Calambur, MD</creatorcontrib><creatorcontrib>Shivkumar, Kalyanam, MD</creatorcontrib><creatorcontrib>Natale, Andrea, MD, FACC, FHRS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart rhythm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santangeli, Pasquale</au><au>Di Biase, Luigi, MD</au><au>Lakkireddy, Dhanunjay, MD</au><au>Burkhardt, J. David, MD</au><au>Pillarisetti, Jayasree, MD</au><au>Michowitz, Yoav, MD</au><au>Sanchez, Javier E., MD</au><au>Horton, Rodney, MD</au><au>Mohanty, Prasant, MBBS, MPH</au><au>Gallinghouse, G. Joseph, MD</au><au>Dello Russo, Antonio, MD</au><au>Casella, Michela, MD</au><au>Pelargonio, Gemma, MD</au><au>Santarelli, Pietro, MD</au><au>Verma, Atul, MD</au><au>Narasimhan, Calambur, MD</au><au>Shivkumar, Kalyanam, MD</au><au>Natale, Andrea, MD, FACC, FHRS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: safety and feasibility</atitle><jtitle>Heart rhythm</jtitle><addtitle>Heart Rhythm</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>7</volume><issue>8</issue><spage>1036</spage><epage>1042</epage><pages>1036-1042</pages><issn>1547-5271</issn><eissn>1556-3871</eissn><abstract>Background Management of ventricular tachycardia (VT) in patients with hypertrophic cardiomyopathy (HCM) is challenging. Objective The purpose of this study is to assess the value of radiofrequency catheter ablation (RFCA) for the treatment of the VTs in the setting of HCM. Methods Twenty-two patients (18 with ICD) with HCM and multiple episodes of VTs resistant to medical therapy underwent RFCA with an open irrigation catheter. Epicardial access was obtained if required. All patients were followed for at least 1 year after RFCA. Results Mean age was 50.4 ± 15.3, and mean ejection fraction was 34.3% ± 9.8%. RFCA was performed endocardially in all patients, while epicardial radiofrequency applications were needed in 13 patients. A previous endocardial ablation was unsuccessful in six patients. At 20 ± 9 months of follow-up, elimination of VTs reached 73%. No major complication was observed during and after the procedures in all patients. Conclusion Catheter ablation of VTs in patients with hypertrophic cardiomyopathy refractory to medical therapy is safe, feasible, and successful in eliminating VT. Epicardial VT mapping and ablation should be considered as an important access option for the treatment of these patients to increase the success rate.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20493276</pmid><doi>10.1016/j.hrthm.2010.05.022</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Cardiomyopathy, Hypertrophic - complications Cardiovascular Catheter Ablation Female Humans Hypertrophic cardiomyopathy Male Middle Aged Outcomes Tachycardia, Ventricular - etiology Tachycardia, Ventricular - surgery Treatment Outcome Ventricular tachycardia |
| title | Radiofrequency catheter ablation of ventricular arrhythmias in patients with hypertrophic cardiomyopathy: safety and feasibility |
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