JNK signalling in human and experimental renal ischaemia/reperfusion injury

Background. Ischaemia/reperfusion (I/R) is an important factor in delayed graft function in renal transplantation and is a determinant of long-term graft outcome. This study examined the role of c-Jun N-terminal kinase (JNK) signalling in human and experimental renal I/R injury. Methods. Biopsies ob...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2010-09, Vol.25 (9), p.2898-2908
Hauptverfasser:	Kanellis, John, Ma, Frank Y., Kandane-Rathnayake, Rangi, Dowling, John P., Polkinghorne, Kevan R., Bennett, Brydon L., Friedman, Glenn C., Nikolic-Paterson, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - complications Acute Kidney Injury - prevention & control Acute Kidney Injury - therapy Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals apoptosis Biological and medical sciences Blotting, Western c-Jun Disease Models, Animal Emergency and intensive care: renal failure. Dialysis management Humans Immunoenzyme Techniques Inflammation Mediators - metabolism Intensive care medicine ischaemia/reperfusion JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism kidney transplant Kidney Transplantation macrophage Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pyrazolones - pharmacology Rats Rats, Sprague-Dawley Renal failure Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction
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