Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method

Establishing a method to evaluate the reliability of an optimal solution is an exciting challenge for the nonlinear response surface method. We reported previously that the bootstrap (BS) resampling technique and Kohonen's self-organizing map are promising tools for meeting this challenge. To u...

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Veröffentlicht in:International journal of pharmaceutics 2010-08, Vol.396 (1), p.75-82
Hauptverfasser: Onuki, Yoshinori, Kikuchi, Shingo, Yasuda, Akihito, Takayama, Kozo
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Sprache:eng
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