Functional Analysis, Overexpression, and Kinetic Characterization of Pyruvate Kinase from Methicillin-Resistant Staphylococcus aureus

Novel antimicrobial targets are urgently needed to overcome rising antibiotic resistance of important human pathogens including methicillin-resistant Staphylococcus aureus (MRSA). Here we report the essentiality and kinetic properties of MRSA pyruvate kinase (PK). Targetron-mediated gene disruption...

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Veröffentlicht in:	Biochemistry (Easton) 2010-09, Vol.49 (35), p.7733-7747
Hauptverfasser:	Zoraghi, Roya, See, Raymond H, Gong, Huansheng, Lian, Tian, Swayze, Rick, Finlay, B. Brett, Brunham, Robert C, McMaster, William R, Reiner, Neil E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Kinetics Methicillin-Resistant Staphylococcus aureus - enzymology Methicillin-Resistant Staphylococcus aureus - growth & development Methicillin-Resistant Staphylococcus aureus - metabolism Molecular Sequence Data Phylogeny Pyruvate Kinase - chemistry Pyruvate Kinase - genetics Pyruvate Kinase - metabolism Thermodynamics
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