Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats

Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH. To assess the effect of the adrenergic receptor blocker carvedilol on th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of respiratory and critical care medicine 2010-09, Vol.182 (5), p.652-660
Hauptverfasser:	Bogaard, Harm J, Natarajan, Ramesh, Mizuno, Shiro, Abbate, Antonio, Chang, Philip J, Chau, Vinh Q, Hoke, Nicholas N, Kraskauskas, Donatas, Kasper, Michael, Salloum, Fadi N, Voelkel, Norbert F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Antagonists - pharmacology Adrenergic receptors Animals Carbazoles - pharmacology Cardiac arrhythmia Clinical trials Disease Models, Animal Heart failure Heart rate Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Hypoxia Indoles - administration & dosage Kinases Male Mortality Propanolamines - pharmacology Proteins Pulmonary Circulation - drug effects Pulmonary hypertension Pyrroles - administration & dosage Rats Rats, Sprague-Dawley Vascular endothelial growth factor Vascular Endothelial Growth Factor A - administration & dosage Vascular Endothelial Growth Factor A - antagonists & inhibitors Ventricular Dysfunction, Right - chemically induced Ventricular Dysfunction, Right - drug therapy Ventricular Remodeling - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!