Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents
An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregn...
Gespeichert in:
| Veröffentlicht in: | Steroids 2010-12, Vol.75 (12), p.805-809 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 809 |
|---|---|
| container_issue | 12 |
| container_start_page | 805 |
| container_title | Steroids |
| container_volume | 75 |
| creator | Banday, Abid H. Mir, Bilal P. Lone, Imtiyaz H. Suri, K.A. Kumar, H.M. Sampath |
| description | An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds
4b,
4c,
4e,
4f,
4h and
4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines. |
| doi_str_mv | 10.1016/j.steroids.2010.02.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_749011360</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0039128X1000053X</els_id><sourcerecordid>749011360</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-1576824ef152e267cbc8b464a9f3ee141de7bda5c83537ee003ddfe6f59aa2b43</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhq2qCJYtfwHlgnrK1l-xkxuIAq2ExAEq7c1y7AnyKhtvPQ4S_fU12oUeexpp5nln7IeQc0ZXjDL1bbPCDCkGjytOS5PyFWXyE1mwVrd10yr9mSwoFV3NeLs-IaeIG0qpEh0_JieccqqUlAuyfsyzD4BVnKopvsBYfa9TmJ4rnHvMIc8ZfHU4Zcdq95rsnziGqSQsVruYYcqhDGwpzk4OUmWfSw-_kKPBjghnh7okv25vnq5_1PcPdz-vr-5rJzqda9Zo1XIJA2s4cKVd79peKmm7QQAwyTzo3tvGtaIRGqB8yfsB1NB01vJeiiX5ut-7S_H3DJjNNqCDcbQTxBmNlh1lTChaSLUnXYqICQazS2Fr06th1LxJNRvzLtW8STWUmyK1BM8PJ-Z-C_4j9m6xABcHwKKz45CKiID_OMF0pzpWuMs9B0XIS4Bk0AUo0nxI4LLxMfzvLX8BoSaa9Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>749011360</pqid></control><display><type>article</type><title>Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Banday, Abid H. ; Mir, Bilal P. ; Lone, Imtiyaz H. ; Suri, K.A. ; Kumar, H.M. Sampath</creator><creatorcontrib>Banday, Abid H. ; Mir, Bilal P. ; Lone, Imtiyaz H. ; Suri, K.A. ; Kumar, H.M. Sampath</creatorcontrib><description>An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds
4b,
4c,
4e,
4f,
4h and
4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/j.steroids.2010.02.014</identifier><identifier>PMID: 20206644</identifier><identifier>CODEN: STEDAM</identifier><language>eng</language><publisher>Kidlington: Elsevier Inc</publisher><subject>Aldehydes - chemistry ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Benzylidene Compounds - chemistry ; Benzylidines ; Biological and medical sciences ; Cell Line, Tumor ; Dipolar cycloaddition ; Fundamental and applied biological sciences. Psychology ; Humans ; Pregnenolone ; Pregnenolone - analogs & derivatives ; Pregnenolone - chemical synthesis ; Pregnenolone - pharmacology ; Pyrazoles - chemistry ; Pyrazoline ; Vertebrates: endocrinology</subject><ispartof>Steroids, 2010-12, Vol.75 (12), p.805-809</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-1576824ef152e267cbc8b464a9f3ee141de7bda5c83537ee003ddfe6f59aa2b43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0039128X1000053X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23179691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20206644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banday, Abid H.</creatorcontrib><creatorcontrib>Mir, Bilal P.</creatorcontrib><creatorcontrib>Lone, Imtiyaz H.</creatorcontrib><creatorcontrib>Suri, K.A.</creatorcontrib><creatorcontrib>Kumar, H.M. Sampath</creatorcontrib><title>Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents</title><title>Steroids</title><addtitle>Steroids</addtitle><description>An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds
4b,
4c,
4e,
4f,
4h and
4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines.</description><subject>Aldehydes - chemistry</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Benzylidene Compounds - chemistry</subject><subject>Benzylidines</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Dipolar cycloaddition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Pregnenolone</subject><subject>Pregnenolone - analogs & derivatives</subject><subject>Pregnenolone - chemical synthesis</subject><subject>Pregnenolone - pharmacology</subject><subject>Pyrazoles - chemistry</subject><subject>Pyrazoline</subject><subject>Vertebrates: endocrinology</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qCJYtfwHlgnrK1l-xkxuIAq2ExAEq7c1y7AnyKhtvPQ4S_fU12oUeexpp5nln7IeQc0ZXjDL1bbPCDCkGjytOS5PyFWXyE1mwVrd10yr9mSwoFV3NeLs-IaeIG0qpEh0_JieccqqUlAuyfsyzD4BVnKopvsBYfa9TmJ4rnHvMIc8ZfHU4Zcdq95rsnziGqSQsVruYYcqhDGwpzk4OUmWfSw-_kKPBjghnh7okv25vnq5_1PcPdz-vr-5rJzqda9Zo1XIJA2s4cKVd79peKmm7QQAwyTzo3tvGtaIRGqB8yfsB1NB01vJeiiX5ut-7S_H3DJjNNqCDcbQTxBmNlh1lTChaSLUnXYqICQazS2Fr06th1LxJNRvzLtW8STWUmyK1BM8PJ-Z-C_4j9m6xABcHwKKz45CKiID_OMF0pzpWuMs9B0XIS4Bk0AUo0nxI4LLxMfzvLX8BoSaa9Q</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Banday, Abid H.</creator><creator>Mir, Bilal P.</creator><creator>Lone, Imtiyaz H.</creator><creator>Suri, K.A.</creator><creator>Kumar, H.M. Sampath</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents</title><author>Banday, Abid H. ; Mir, Bilal P. ; Lone, Imtiyaz H. ; Suri, K.A. ; Kumar, H.M. Sampath</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-1576824ef152e267cbc8b464a9f3ee141de7bda5c83537ee003ddfe6f59aa2b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aldehydes - chemistry</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Benzylidene Compounds - chemistry</topic><topic>Benzylidines</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Dipolar cycloaddition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Pregnenolone</topic><topic>Pregnenolone - analogs & derivatives</topic><topic>Pregnenolone - chemical synthesis</topic><topic>Pregnenolone - pharmacology</topic><topic>Pyrazoles - chemistry</topic><topic>Pyrazoline</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banday, Abid H.</creatorcontrib><creatorcontrib>Mir, Bilal P.</creatorcontrib><creatorcontrib>Lone, Imtiyaz H.</creatorcontrib><creatorcontrib>Suri, K.A.</creatorcontrib><creatorcontrib>Kumar, H.M. Sampath</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banday, Abid H.</au><au>Mir, Bilal P.</au><au>Lone, Imtiyaz H.</au><au>Suri, K.A.</au><au>Kumar, H.M. Sampath</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>75</volume><issue>12</issue><spage>805</spage><epage>809</epage><pages>805-809</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><coden>STEDAM</coden><abstract>An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds
4b,
4c,
4e,
4f,
4h and
4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>20206644</pmid><doi>10.1016/j.steroids.2010.02.014</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 2010-12, Vol.75 (12), p.805-809 |
| issn | 0039-128X 1878-5867 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_749011360 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aldehydes - chemistry Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzylidene Compounds - chemistry Benzylidines Biological and medical sciences Cell Line, Tumor Dipolar cycloaddition Fundamental and applied biological sciences. Psychology Humans Pregnenolone Pregnenolone - analogs & derivatives Pregnenolone - chemical synthesis Pregnenolone - pharmacology Pyrazoles - chemistry Pyrazoline Vertebrates: endocrinology |
| title | Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T18%3A54%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20novel%20D-ring%20substituted%20steroidal%20pyrazolines%20as%20potential%20anticancer%20agents&rft.jtitle=Steroids&rft.au=Banday,%20Abid%20H.&rft.date=2010-12-01&rft.volume=75&rft.issue=12&rft.spage=805&rft.epage=809&rft.pages=805-809&rft.issn=0039-128X&rft.eissn=1878-5867&rft.coden=STEDAM&rft_id=info:doi/10.1016/j.steroids.2010.02.014&rft_dat=%3Cproquest_cross%3E749011360%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=749011360&rft_id=info:pmid/20206644&rft_els_id=S0039128X1000053X&rfr_iscdi=true |