D-ring substituted 1,2,3-triazolyl 20-keto pregnenanes as potential anticancer agents: Synthesis and biological evaluation

A facile synthesis of 21-triazolyl derivatives of pregnenolone and their potential antitumour activity is reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to 21-bromo pregnenolone and finally the one-pot, two-step in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Steroids 2010-12, Vol.75 (12), p.801-804
Hauptverfasser:	Banday, Abid H., Shameem, Shameem A., Gupta, B.D., Kumar, H.M. Sampath
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylene - chemistry Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Azides - chemistry Biological and medical sciences Catalysis Cell Line, Tumor Click chemistry Copper - chemistry Fundamental and applied biological sciences. Psychology Humans Inhibitory Concentration 50 Pregnenes - chemical synthesis Pregnenes - chemistry Pregnenes - pharmacology Pregnenolone Stereoisomerism Substrate Specificity Triazoles Triazoles - chemistry Vertebrates: endocrinology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!