Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells

Histone deacetylase inhibitors (HDACis) have received considerable attention for their anti‐tumoral properties. We report here the effects of two HDACis, SAHA and MS‐275, on the biology of mesenchymal stem cells (MSCs). It is well known that HDACis trigger both DNA damage responses and actual DNA da...

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Veröffentlicht in:	Journal of cellular physiology 2010-11, Vol.225 (2), p.537-544
Hauptverfasser:	Di Bernardo, Giovanni, Alessio, Nicola, Dell'Aversana, Carmela, Casale, Fiorina, Teti, Diana, Cipollaro, Marilena, Altucci, Lucia, Galderisi, Umberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Benzamides - pharmacology DNA Damage - physiology DNA Repair - drug effects Gene Expression Profiling Gene Expression Regulation - physiology Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - physiology Pyridines - pharmacology Vorinostat
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