Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery

The aim of the present study was to examine the effect of an early stage of streptozotocin-induced diabetes on the mechanism(s) of endothelium-dependent relaxation. Diabetes was induced by a single injection of streptozotocin (48 mg/kg iv), and the ACh-induced relaxation of rat carotid arteries was...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2010-08, Vol.299 (2), p.H502-H511
Hauptverfasser:	Leo, C H, Joshi, A, Woodman, O L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Body Weight Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - physiopathology Caveolin 1 - metabolism Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Diabetic Angiopathies - etiology Diabetic Angiopathies - metabolism Diabetic Angiopathies - physiopathology Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Enzyme Inhibitors - pharmacology Free Radical Scavengers - pharmacology Guanylate Cyclase - antagonists & inhibitors Guanylate Cyclase - metabolism Ion Channel Gating Male Membrane Glycoproteins - metabolism NADPH Oxidase 2 NADPH Oxidases - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - metabolism Potassium Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - metabolism Protein Multimerization Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism Rodents S-Nitrosothiols - metabolism Soluble Guanylyl Cyclase Time Factors Vasodilation - drug effects Vasodilator Agents - pharmacology Veins & arteries
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