The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor
Abstract Objective To determine the effects of ritodrine and magnesium sulfate on maternal–fetal blood flows. Study design A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to r...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2010-09, Vol.152 (1), p.50-54 |
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| creator | Sayin, N. Cenk Arda, Sezer Varol, Füsun G Süt, Necdet |
| description | Abstract Objective To determine the effects of ritodrine and magnesium sulfate on maternal–fetal blood flows. Study design A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) ( n = 46) or magnesium sulfate ( n = 39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy. Results UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Conclusions MgSO4 and ritodrine affect blood flow patterns after 48 h in some maternal–fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO4. |
| doi_str_mv | 10.1016/j.ejogrb.2010.05.021 |
| format | Article |
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Cenk ; Arda, Sezer ; Varol, Füsun G ; Süt, Necdet</creator><creatorcontrib>Sayin, N. Cenk ; Arda, Sezer ; Varol, Füsun G ; Süt, Necdet</creatorcontrib><description>Abstract Objective To determine the effects of ritodrine and magnesium sulfate on maternal–fetal blood flows. Study design A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) ( n = 46) or magnesium sulfate ( n = 39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy. Results UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Conclusions MgSO4 and ritodrine affect blood flow patterns after 48 h in some maternal–fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO4.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2010.05.021</identifier><identifier>PMID: 20561741</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Cardiovascular system ; Diseases of mother, fetus and pregnancy ; Doppler ; Female ; Fetus - blood supply ; Fetus - drug effects ; Gynecology. Andrology. Obstetrics ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnesium sulfate ; Magnesium Sulfate - administration & dosage ; Medical sciences ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - drug effects ; Obstetric Labor, Premature - drug therapy ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy. Fetus. Placenta ; Preterm ; Pulsatile Flow - drug effects ; Ritodrine ; Ritodrine - administration & dosage ; Tocolysis ; Tocolytic Agents - administration & dosage ; Ultrasonic investigative techniques ; Ultrasonography, Doppler ; Ultrasonography, Prenatal - drug effects ; Umbilical Arteries - diagnostic imaging ; Umbilical Arteries - drug effects ; Umbilical Veins - diagnostic imaging ; Umbilical Veins - drug effects ; Uterine Artery - diagnostic imaging ; Uterine Artery - drug effects ; Verapamil - administration & dosage ; Young Adult</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2010-09, Vol.152 (1), p.50-54</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Crown Copyright 2010. Published by Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-edb5b19b89ff66d48506dc19259db3a4b9f0f8393825b39d533377c6c5a383ff3</citedby><cites>FETCH-LOGICAL-c446t-edb5b19b89ff66d48506dc19259db3a4b9f0f8393825b39d533377c6c5a383ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211510002666$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23247872$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20561741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sayin, N. Cenk</creatorcontrib><creatorcontrib>Arda, Sezer</creatorcontrib><creatorcontrib>Varol, Füsun G</creatorcontrib><creatorcontrib>Süt, Necdet</creatorcontrib><title>The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective To determine the effects of ritodrine and magnesium sulfate on maternal–fetal blood flows. Study design A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) ( n = 46) or magnesium sulfate ( n = 39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy. Results UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Conclusions MgSO4 and ritodrine affect blood flow patterns after 48 h in some maternal–fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO4.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Cardiovascular system</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Doppler</subject><subject>Female</subject><subject>Fetus - blood supply</subject><subject>Fetus - drug effects</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnesium sulfate</subject><subject>Magnesium Sulfate - administration & dosage</subject><subject>Medical sciences</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - drug effects</subject><subject>Obstetric Labor, Premature - drug therapy</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Preterm</subject><subject>Pulsatile Flow - drug effects</subject><subject>Ritodrine</subject><subject>Ritodrine - administration & dosage</subject><subject>Tocolysis</subject><subject>Tocolytic Agents - administration & dosage</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler</subject><subject>Ultrasonography, Prenatal - drug effects</subject><subject>Umbilical Arteries - diagnostic imaging</subject><subject>Umbilical Arteries - drug effects</subject><subject>Umbilical Veins - diagnostic imaging</subject><subject>Umbilical Veins - drug effects</subject><subject>Uterine Artery - diagnostic imaging</subject><subject>Uterine Artery - drug effects</subject><subject>Verapamil - administration & dosage</subject><subject>Young Adult</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuKFTEQhhtRnOPoG4hkI676mHt3bwQZrzDgwnEdcqnM5JjutEm3w4APb9pzVHBjFknx81VV-Kua5inBe4KJfHnYwyFdZ7OnuEpY7DEl95od6TvadlLw-80OM0xaSog4ax6VcsD1MDY8bM4oFpJ0nOyaH1c3gMB7sEtByaMcluRymADpyaFRX09QwjqiskavF0BpquICedLxF-FhqdGbNM8RMjIxparFdItmvWxYQWFCt2mEeoflBs0ZqjyiqE3Kj5sHXscCT07vefPl3duriw_t5af3Hy9eX7aWc7m04IwwZDD94L2UjvcCS2fJQMXgDNPcDB77ng2sp8KwwQnGWNdZaYVmPfOenTcvjnXnnL6tUBY1hmIhRj1BWovq-IAxF4xUkh9Jm1MpGbyacxh1vlMEq812dVBH29Vmu8JCVdtr2rNTg9WM4P4k_fa5As9PgC5WR5_1ZEP5yzHKuzq4yr06clDt-B4gq2IDTBZcyHVEyqXwv5_8W8DGMIXa8yvcQTmkdRtdUUQVqrD6vK3ItiGk7gaVUrKf22O4Xw</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Sayin, N. Cenk</creator><creator>Arda, Sezer</creator><creator>Varol, Füsun G</creator><creator>Süt, Necdet</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100901</creationdate><title>The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor</title><author>Sayin, N. Cenk ; Arda, Sezer ; Varol, Füsun G ; Süt, Necdet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-edb5b19b89ff66d48506dc19259db3a4b9f0f8393825b39d533377c6c5a383ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Cardiovascular system</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Doppler</topic><topic>Female</topic><topic>Fetus - blood supply</topic><topic>Fetus - drug effects</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnesium sulfate</topic><topic>Magnesium Sulfate - administration & dosage</topic><topic>Medical sciences</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - drug effects</topic><topic>Obstetric Labor, Premature - drug therapy</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Preterm</topic><topic>Pulsatile Flow - drug effects</topic><topic>Ritodrine</topic><topic>Ritodrine - administration & dosage</topic><topic>Tocolysis</topic><topic>Tocolytic Agents - administration & dosage</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Doppler</topic><topic>Ultrasonography, Prenatal - drug effects</topic><topic>Umbilical Arteries - diagnostic imaging</topic><topic>Umbilical Arteries - drug effects</topic><topic>Umbilical Veins - diagnostic imaging</topic><topic>Umbilical Veins - drug effects</topic><topic>Uterine Artery - diagnostic imaging</topic><topic>Uterine Artery - drug effects</topic><topic>Verapamil - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sayin, N. Cenk</creatorcontrib><creatorcontrib>Arda, Sezer</creatorcontrib><creatorcontrib>Varol, Füsun G</creatorcontrib><creatorcontrib>Süt, Necdet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sayin, N. Cenk</au><au>Arda, Sezer</au><au>Varol, Füsun G</au><au>Süt, Necdet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>152</volume><issue>1</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Abstract Objective To determine the effects of ritodrine and magnesium sulfate on maternal–fetal blood flows. Study design A total of 85 pregnant women between 26th and 36th weeks with preterm labor, and 83 healthy pregnant women were included. Patients in the study group were randomly assigned to receive either ritodrine (with the addition of verapamil) ( n = 46) or magnesium sulfate ( n = 39). Blood flow examinations on the umbilical artery (UA), middle cerebral artery (MCA), bilateral uterine arteries (Ut.A) and ductus venosus (DV) were performed before and 48 h after initiating therapy. Results UA pulsatility index (PI) significantly differed in women receiving tocolysis compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Ut.A values did not significantly change after 48 h in the groups. In women between the 26th and 32nd weeks, UA, MCA and DV PI did not significantly change after 48 h in the three groups. However, in women between the 32nd and 36th weeks UA and MCA PI significantly differed in the treatment groups compared to controls after 48 h. DV PI increased in women receiving MgSO4 , whereas it decreased in the ritodrine and control groups. Conclusions MgSO4 and ritodrine affect blood flow patterns after 48 h in some maternal–fetal vessels. These effects on blood flow are particularly significant in women between 32nd and 36th weeks. The effects of both drugs on fetal and maternal Doppler flows seem similar, except the increased resistance to flow in DV in women receiving MgSO4.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20561741</pmid><doi>10.1016/j.ejogrb.2010.05.021</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood Flow Velocity - drug effects Cardiovascular system Diseases of mother, fetus and pregnancy Doppler Female Fetus - blood supply Fetus - drug effects Gynecology. Andrology. Obstetrics Humans Investigative techniques, diagnostic techniques (general aspects) Magnesium sulfate Magnesium Sulfate - administration & dosage Medical sciences Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - drug effects Obstetric Labor, Premature - drug therapy Obstetrics and Gynecology Pregnancy Pregnancy. Fetus. Placenta Preterm Pulsatile Flow - drug effects Ritodrine Ritodrine - administration & dosage Tocolysis Tocolytic Agents - administration & dosage Ultrasonic investigative techniques Ultrasonography, Doppler Ultrasonography, Prenatal - drug effects Umbilical Arteries - diagnostic imaging Umbilical Arteries - drug effects Umbilical Veins - diagnostic imaging Umbilical Veins - drug effects Uterine Artery - diagnostic imaging Uterine Artery - drug effects Verapamil - administration & dosage Young Adult |
| title | The effects of ritodrine and magnesium sulfate on maternal and fetal Doppler blood flow patterns in women with preterm labor |
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