Direct Asymmetric Hydrogenation of 2-Oxo-4-arylbut-3-enoic Acids

A challenging direct asymmetric hydrogenation of (E)-2-oxo-4-arylbut-3-enoic acids to give 2-hydroxy-4-arylbutanoic acids (85.4−91.8% ee) was achieved with a Ru catalyst based on SunPhos as the chiral ligand. Further investigation of the reaction revealed that partial isomerization of 2-hydroxy-4-ar...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of organic chemistry 2010-09, Vol.75 (17), p.6027-6030
Hauptverfasser:	Zhu, Lvfeng, Meng, Qinghua, Fan, Weizheng, Xie, Xiaomin, Zhang, Zhaoguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Butyrates - chemical synthesis Butyrates - chemistry Catalysis Catalysts: preparations and properties Chemistry Exact sciences and technology General and physical chemistry Hydrogenation Molecular Structure Organic chemistry Preparations and properties Stereoisomerism Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!