Synthesis of 5-Amino-oxazole-4-carboxylates from α-Chloroglycinates

Synthesis of 5-Amino-oxazole-4-carboxylates from α-Chloroglycinates

Aluminum-based Lewis acids are effective promoters of the condensation of α-chloroglycinates with isonitriles or with cyanide ion, leading to the formation of 5-amino-oxazoles.

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Veröffentlicht in:Organic letters 2010-09, Vol.12 (17), p.3942-3945
Hauptverfasser: Zhang, Jianmin, Coqueron, Pierre-Yves, Vors, Jean-Pierre, Ciufolini, Marco A
Format: Artikel
Sprache:eng
Schlagworte:
Aluminum - chemistry
Amines - chemical synthesis
Amines - chemistry
Carboxylic Acids - chemical synthesis
Carboxylic Acids - chemistry
Combinatorial Chemistry Techniques
Esters
Glycine - analogs & derivatives
Glycine - chemistry
Hydrocarbons, Chlorinated - chemistry
Lewis Acids - chemistry
Molecular Structure
Nitriles - chemistry
Oxazoles - chemical synthesis
Oxazoles - chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:Aluminum-based Lewis acids are effective promoters of the condensation of α-chloroglycinates with isonitriles or with cyanide ion, leading to the formation of 5-amino-oxazoles.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101704r