Sex difference in Aroclor 1254 induction of rat hepatocytes: Consequences for in vitro embryotoxicity and mutagenicity of cyclophosphamide

The sequential culture of rat hepatocytes and post-implantation rat embryos has been proposed as a model for the in vitro testing of pro-teratogens. Comparing this model with a model in which embryos and hepatocytes are cultured simultaneously a striking difference in sensitivity was noted. To addre...

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Veröffentlicht in:	Toxicology in vitro 1993-11, Vol.7 (6), p.769-775
Hauptverfasser:	van Aerts, L.A.G.J.M., Hahné, S.J.M., Oostendorp, A.G.M., Pertijs, J.C.L.M., Fijneman, P.H.S., Bos, R.P., Copius Peereboom, J.H.J., Noordhoek, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug toxicity and drugs side effects treatment Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments
Online-Zugang:	Volltext
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