Abnormal visual activation in Parkinson's disease patients
Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 1...
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| Veröffentlicht in: | Movement disorders 2010-08, Vol.25 (11), p.1590-1596 |
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| creator | Cardoso, Ellison Fernando Fregni, Felipe Maia, Fernanda Martins Melo, Luciano M. Sato, João R. Cruz Jr, Antonio Cesário Bianchi, Edno Tales Fernandes, Danilo Botelho Monteiro, Mário Luiz Ribeiro Barbosa, Egberto Reis Amaro Jr, Edson |
| description | Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society |
| doi_str_mv | 10.1002/mds.23101 |
| format | Article |
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To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.23101</identifier><identifier>PMID: 20623771</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Analysis of Variance ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Disord</addtitle><description>Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society</description><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>dopamine</subject><subject>Face</subject><subject>Female</subject><subject>fMRI</subject><subject>hallucinations</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurologic Examination - methods</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Oxygen - blood</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Perceptual Disorders - etiology</subject><subject>Photic Stimulation - methods</subject><subject>Statistics as Topic</subject><subject>Visual Cortex - blood supply</subject><subject>Visual Cortex - physiopathology</subject><subject>Visual Pathways - blood supply</subject><subject>Visual Pathways - physiopathology</subject><subject>visual symptoms</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EglJY8AMoG1SxCHhsJ47ZlfIoEi8JBEvLSRzJkEfJJIX-PYYWWLEaaebcmdEhZA_oEVDKjqscjxgHCmtkABGHMGGRXCcDmiRRyCGJtsg24gulABHEm2SL0ZhxKWFATsZp3bSVKYO5w94Xk3VubjrX1IGrg3vTvroam3qEQe7QGrTBzE9t3eEO2ShMiXZ3VYfk8eL8cTINr-8urybj6zDjikEo_ItFWkRMiCTzLZqLjFlqJVeKcmksSxSTqYGisCZSqYiNSrmJwQpI85QPyWi5dtY2b73FTlcOM1uWprZNj1qKRCnBpPLk4ZLM2gaxtYWeta4y7UID1V-itBelv0V5dn-1tU8rm_-SP2Y8cLACDGamLFpTZw7_OA6xAKCeO15y7660i_8v6puzh5_T4TLhsLMfvwlvWseSy0g_317qyfT04YlOYh_-BNYUjSw</recordid><startdate>20100815</startdate><enddate>20100815</enddate><creator>Cardoso, Ellison Fernando</creator><creator>Fregni, Felipe</creator><creator>Maia, Fernanda Martins</creator><creator>Melo, Luciano M.</creator><creator>Sato, João R.</creator><creator>Cruz Jr, Antonio Cesário</creator><creator>Bianchi, Edno Tales</creator><creator>Fernandes, Danilo Botelho</creator><creator>Monteiro, Mário Luiz Ribeiro</creator><creator>Barbosa, Egberto Reis</creator><creator>Amaro Jr, Edson</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100815</creationdate><title>Abnormal visual activation in Parkinson's disease patients</title><author>Cardoso, Ellison Fernando ; Fregni, Felipe ; Maia, Fernanda Martins ; Melo, Luciano M. ; Sato, João R. ; Cruz Jr, Antonio Cesário ; Bianchi, Edno Tales ; Fernandes, Danilo Botelho ; Monteiro, Mário Luiz Ribeiro ; Barbosa, Egberto Reis ; Amaro Jr, Edson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3921-4100fbf52448cc390d4c2e0e7399037ae28927ba1ffea59b46a9b3a61e41bdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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Prion diseases</topic><topic>dopamine</topic><topic>Face</topic><topic>Female</topic><topic>fMRI</topic><topic>hallucinations</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurologic Examination - methods</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Oxygen - blood</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><topic>Pattern Recognition, Visual - physiology</topic><topic>Perceptual Disorders - etiology</topic><topic>Photic Stimulation - methods</topic><topic>Statistics as Topic</topic><topic>Visual Cortex - blood supply</topic><topic>Visual Cortex - physiopathology</topic><topic>Visual Pathways - blood supply</topic><topic>Visual Pathways - physiopathology</topic><topic>visual symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardoso, Ellison Fernando</creatorcontrib><creatorcontrib>Fregni, Felipe</creatorcontrib><creatorcontrib>Maia, Fernanda Martins</creatorcontrib><creatorcontrib>Melo, Luciano M.</creatorcontrib><creatorcontrib>Sato, João R.</creatorcontrib><creatorcontrib>Cruz Jr, Antonio Cesário</creatorcontrib><creatorcontrib>Bianchi, Edno Tales</creatorcontrib><creatorcontrib>Fernandes, Danilo Botelho</creatorcontrib><creatorcontrib>Monteiro, Mário Luiz Ribeiro</creatorcontrib><creatorcontrib>Barbosa, Egberto Reis</creatorcontrib><creatorcontrib>Amaro Jr, Edson</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardoso, Ellison Fernando</au><au>Fregni, Felipe</au><au>Maia, Fernanda Martins</au><au>Melo, Luciano M.</au><au>Sato, João R.</au><au>Cruz Jr, Antonio Cesário</au><au>Bianchi, Edno Tales</au><au>Fernandes, Danilo Botelho</au><au>Monteiro, Mário Luiz Ribeiro</au><au>Barbosa, Egberto Reis</au><au>Amaro Jr, Edson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal visual activation in Parkinson's disease patients</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. 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| subjects | Aged Analysis of Variance Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dopamine Face Female fMRI hallucinations Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neurologic Examination - methods Neurology Neuropsychological Tests Oxygen - blood Parkinson Disease - complications Parkinson Disease - pathology Parkinson's disease Pattern Recognition, Visual - physiology Perceptual Disorders - etiology Photic Stimulation - methods Statistics as Topic Visual Cortex - blood supply Visual Cortex - physiopathology Visual Pathways - blood supply Visual Pathways - physiopathology visual symptoms |
| title | Abnormal visual activation in Parkinson's disease patients |
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