Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant
Introduction The purpose of this study was to evaluate the acute fixation strength of fibrin sealant as an alternative fixation method for laparoscopic ventral hernia repair (LVHR) when utilized with absorbable and nonabsorbable barrier meshes. Methods Representative mesh types for LVHR included one...
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| Veröffentlicht in: | Hernia : the journal of hernias and abdominal wall surgery 2010-10, Vol.14 (5), p.505-509 |
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| creator | Jenkins, E. D. Melman, L. Frisella, M. M. Deeken, C. R. Matthews, B. D. |
| description | Introduction
The purpose of this study was to evaluate the acute fixation strength of fibrin sealant as an alternative fixation method for laparoscopic ventral hernia repair (LVHR) when utilized with absorbable and nonabsorbable barrier meshes.
Methods
Representative mesh types for LVHR included one nonabsorbable barrier mesh (Bard
®
Composix™) and three absorbable barrier meshes (Sepramesh™, Proceed™, and Parietex™ Composite Mesh). Macroporous polypropylene mesh (Prolite Ultra™) served as a control. An associated pilot study demonstrated that acute fixation was not achieved with C-Qur™ or Dualmesh
®
, thus these meshes were not subjected to further analysis. Two fibrin sealants varying in thrombin concentration (TISSEEL™ 500 IU/ml or ARTISS™ 4 IU/ml) were each utilized to secure a 3 × 4 cm piece of mesh to the peritoneal surface of harvested abdominal wall from New Zealand white rabbits. Ten samples were prepared for each mesh and fibrin sealant combination. The resulting mesh-tissue interface (3 × 3 cm) underwent lap shear testing at a rate of 0.42 mm/s using a tensiometer (Instron 5542, Norwood, MA). The maximum load sustained by the construct was recorded as the acute fixation strength in units of Newtons (N). Data are given as means ± SEM. Statistical significance (
P
0.05) in the acute fixation strength achieved by ARTISS™ versus TISSEEL™ with Composix™, Sepramesh™, Proceed™, and Parietex™ Composite Mesh. However, Prolite Ultra™ fixed with ARTISS™ (7.099 ± 1.01 N) had a significantly higher tensile strength (
P
|
| doi_str_mv | 10.1007/s10029-010-0670-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_748989769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2129779631</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-763777d778bad8bc52a81c9baacb6e6c86b8b9c3dd76610ac5296488fb4a494c3</originalsourceid><addsrcrecordid>eNp1kUlPwzAQhS0EoqXwA7igiAungJM4Xo6oKotUiQucrbHjtKnSuNgxy7_HJWUREhcv8755HvkhdJrhywxjduXjmosUZzjFlOG02EPjLCc8FTkm-9szLVMiMB2hI-9XGGNOKD9EoyiXRHAxRmH2Am2AvrFdYusEdOhNUjdvQ8X3znSLfvkpKW-dAtWaBLoq6Wz3q6LAuca4RFvoTZWsjV8m3ujg4uW1iQZ1o1wTDQ200PXH6KCG1puT3T5BTzezx-ldOn-4vZ9ez1NdMNynjBaMsYoxrqDiSpc58EwLBaAVNVRzqrgSuqgqRmmGIQKCEs5rRYAIoosJuhh8N84-B-N7uW68Nm2cwdjgJSM8_gKjIpLnf8iVDa6Lw0VIEJ6XBY9QNkDaWe-dqeXGNWtw7zLDcpuIHBKRMRG5TUQWsedsZxzU2lTfHV8RRCAfAB-lbmHcz8v_u34Aoq-YCQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>749482538</pqid></control><display><type>article</type><title>Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jenkins, E. D. ; Melman, L. ; Frisella, M. M. ; Deeken, C. R. ; Matthews, B. D.</creator><creatorcontrib>Jenkins, E. D. ; Melman, L. ; Frisella, M. M. ; Deeken, C. R. ; Matthews, B. D.</creatorcontrib><description>Introduction
The purpose of this study was to evaluate the acute fixation strength of fibrin sealant as an alternative fixation method for laparoscopic ventral hernia repair (LVHR) when utilized with absorbable and nonabsorbable barrier meshes.
Methods
Representative mesh types for LVHR included one nonabsorbable barrier mesh (Bard
®
Composix™) and three absorbable barrier meshes (Sepramesh™, Proceed™, and Parietex™ Composite Mesh). Macroporous polypropylene mesh (Prolite Ultra™) served as a control. An associated pilot study demonstrated that acute fixation was not achieved with C-Qur™ or Dualmesh
®
, thus these meshes were not subjected to further analysis. Two fibrin sealants varying in thrombin concentration (TISSEEL™ 500 IU/ml or ARTISS™ 4 IU/ml) were each utilized to secure a 3 × 4 cm piece of mesh to the peritoneal surface of harvested abdominal wall from New Zealand white rabbits. Ten samples were prepared for each mesh and fibrin sealant combination. The resulting mesh-tissue interface (3 × 3 cm) underwent lap shear testing at a rate of 0.42 mm/s using a tensiometer (Instron 5542, Norwood, MA). The maximum load sustained by the construct was recorded as the acute fixation strength in units of Newtons (N). Data are given as means ± SEM. Statistical significance (
P
< 0.05) was determined using a two-way ANOVA and Bonferroni post-test.
Results
There was no significant difference (
P
> 0.05) in the acute fixation strength achieved by ARTISS™ versus TISSEEL™ with Composix™, Sepramesh™, Proceed™, and Parietex™ Composite Mesh. However, Prolite Ultra™ fixed with ARTISS™ (7.099 ± 1.01 N) had a significantly higher tensile strength (
P
< 0.001) than Prolite Ultra™ fixed with TISSEEL™ (3.405 ± 0.72 N). Among meshes fixed with TISSEEL™, Parietex™ Composite (3.936 ± 0.73 N) was significantly stronger than Sepramesh™ (1.760 ± 0.33 N) (
P
< 0.05).
Conclusions
Acute fixation strength is equivalent for TISSEEL™ and ARTISS™ fibrin sealants for selected nonabsorbable (Composix™) and absorbable barrier-coated (Sepramesh™, Proceed™, and Parietex™ Composite Mesh) meshes. Previous evaluations in this model indicated fibrin sealant alone did not appear to be a suitable method of fixation with C-Qur™ or DualMesh
®
against the peritoneum. Long-term evaluation is needed to evaluate the efficacy of this method of fixation using absorbable and nonabsorbable barrier-coated meshes in a model of LVHR.</description><identifier>ISSN: 1265-4906</identifier><identifier>EISSN: 1248-9204</identifier><identifier>DOI: 10.1007/s10029-010-0670-3</identifier><identifier>PMID: 20454989</identifier><language>eng</language><publisher>Paris: Springer-Verlag</publisher><subject>Abdominal Surgery ; Animals ; Coated Materials, Biocompatible ; Disease Models, Animal ; Fibrin Tissue Adhesive ; Hernia, Ventral - surgery ; Laparoscopy - methods ; Materials Testing - methods ; Medicine ; Medicine & Public Health ; Original Article ; Polypropylenes ; Polytetrafluoroethylene ; Prosthesis Design ; Rabbits ; Surgical Mesh ; Tensile Strength</subject><ispartof>Hernia : the journal of hernias and abdominal wall surgery, 2010-10, Vol.14 (5), p.505-509</ispartof><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-763777d778bad8bc52a81c9baacb6e6c86b8b9c3dd76610ac5296488fb4a494c3</citedby><cites>FETCH-LOGICAL-c370t-763777d778bad8bc52a81c9baacb6e6c86b8b9c3dd76610ac5296488fb4a494c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10029-010-0670-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10029-010-0670-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20454989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenkins, E. D.</creatorcontrib><creatorcontrib>Melman, L.</creatorcontrib><creatorcontrib>Frisella, M. M.</creatorcontrib><creatorcontrib>Deeken, C. R.</creatorcontrib><creatorcontrib>Matthews, B. D.</creatorcontrib><title>Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant</title><title>Hernia : the journal of hernias and abdominal wall surgery</title><addtitle>Hernia</addtitle><addtitle>Hernia</addtitle><description>Introduction
The purpose of this study was to evaluate the acute fixation strength of fibrin sealant as an alternative fixation method for laparoscopic ventral hernia repair (LVHR) when utilized with absorbable and nonabsorbable barrier meshes.
Methods
Representative mesh types for LVHR included one nonabsorbable barrier mesh (Bard
®
Composix™) and three absorbable barrier meshes (Sepramesh™, Proceed™, and Parietex™ Composite Mesh). Macroporous polypropylene mesh (Prolite Ultra™) served as a control. An associated pilot study demonstrated that acute fixation was not achieved with C-Qur™ or Dualmesh
®
, thus these meshes were not subjected to further analysis. Two fibrin sealants varying in thrombin concentration (TISSEEL™ 500 IU/ml or ARTISS™ 4 IU/ml) were each utilized to secure a 3 × 4 cm piece of mesh to the peritoneal surface of harvested abdominal wall from New Zealand white rabbits. Ten samples were prepared for each mesh and fibrin sealant combination. The resulting mesh-tissue interface (3 × 3 cm) underwent lap shear testing at a rate of 0.42 mm/s using a tensiometer (Instron 5542, Norwood, MA). The maximum load sustained by the construct was recorded as the acute fixation strength in units of Newtons (N). Data are given as means ± SEM. Statistical significance (
P
< 0.05) was determined using a two-way ANOVA and Bonferroni post-test.
Results
There was no significant difference (
P
> 0.05) in the acute fixation strength achieved by ARTISS™ versus TISSEEL™ with Composix™, Sepramesh™, Proceed™, and Parietex™ Composite Mesh. However, Prolite Ultra™ fixed with ARTISS™ (7.099 ± 1.01 N) had a significantly higher tensile strength (
P
< 0.001) than Prolite Ultra™ fixed with TISSEEL™ (3.405 ± 0.72 N). Among meshes fixed with TISSEEL™, Parietex™ Composite (3.936 ± 0.73 N) was significantly stronger than Sepramesh™ (1.760 ± 0.33 N) (
P
< 0.05).
Conclusions
Acute fixation strength is equivalent for TISSEEL™ and ARTISS™ fibrin sealants for selected nonabsorbable (Composix™) and absorbable barrier-coated (Sepramesh™, Proceed™, and Parietex™ Composite Mesh) meshes. Previous evaluations in this model indicated fibrin sealant alone did not appear to be a suitable method of fixation with C-Qur™ or DualMesh
®
against the peritoneum. Long-term evaluation is needed to evaluate the efficacy of this method of fixation using absorbable and nonabsorbable barrier-coated meshes in a model of LVHR.</description><subject>Abdominal Surgery</subject><subject>Animals</subject><subject>Coated Materials, Biocompatible</subject><subject>Disease Models, Animal</subject><subject>Fibrin Tissue Adhesive</subject><subject>Hernia, Ventral - surgery</subject><subject>Laparoscopy - methods</subject><subject>Materials Testing - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Polypropylenes</subject><subject>Polytetrafluoroethylene</subject><subject>Prosthesis Design</subject><subject>Rabbits</subject><subject>Surgical Mesh</subject><subject>Tensile Strength</subject><issn>1265-4906</issn><issn>1248-9204</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUlPwzAQhS0EoqXwA7igiAungJM4Xo6oKotUiQucrbHjtKnSuNgxy7_HJWUREhcv8755HvkhdJrhywxjduXjmosUZzjFlOG02EPjLCc8FTkm-9szLVMiMB2hI-9XGGNOKD9EoyiXRHAxRmH2Am2AvrFdYusEdOhNUjdvQ8X3znSLfvkpKW-dAtWaBLoq6Wz3q6LAuca4RFvoTZWsjV8m3ujg4uW1iQZ1o1wTDQ200PXH6KCG1puT3T5BTzezx-ldOn-4vZ9ez1NdMNynjBaMsYoxrqDiSpc58EwLBaAVNVRzqrgSuqgqRmmGIQKCEs5rRYAIoosJuhh8N84-B-N7uW68Nm2cwdjgJSM8_gKjIpLnf8iVDa6Lw0VIEJ6XBY9QNkDaWe-dqeXGNWtw7zLDcpuIHBKRMRG5TUQWsedsZxzU2lTfHV8RRCAfAB-lbmHcz8v_u34Aoq-YCQ</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Jenkins, E. D.</creator><creator>Melman, L.</creator><creator>Frisella, M. M.</creator><creator>Deeken, C. R.</creator><creator>Matthews, B. D.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant</title><author>Jenkins, E. D. ; Melman, L. ; Frisella, M. M. ; Deeken, C. R. ; Matthews, B. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-763777d778bad8bc52a81c9baacb6e6c86b8b9c3dd76610ac5296488fb4a494c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abdominal Surgery</topic><topic>Animals</topic><topic>Coated Materials, Biocompatible</topic><topic>Disease Models, Animal</topic><topic>Fibrin Tissue Adhesive</topic><topic>Hernia, Ventral - surgery</topic><topic>Laparoscopy - methods</topic><topic>Materials Testing - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Polypropylenes</topic><topic>Polytetrafluoroethylene</topic><topic>Prosthesis Design</topic><topic>Rabbits</topic><topic>Surgical Mesh</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenkins, E. D.</creatorcontrib><creatorcontrib>Melman, L.</creatorcontrib><creatorcontrib>Frisella, M. M.</creatorcontrib><creatorcontrib>Deeken, C. R.</creatorcontrib><creatorcontrib>Matthews, B. D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Hernia : the journal of hernias and abdominal wall surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenkins, E. D.</au><au>Melman, L.</au><au>Frisella, M. M.</au><au>Deeken, C. R.</au><au>Matthews, B. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant</atitle><jtitle>Hernia : the journal of hernias and abdominal wall surgery</jtitle><stitle>Hernia</stitle><addtitle>Hernia</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>14</volume><issue>5</issue><spage>505</spage><epage>509</epage><pages>505-509</pages><issn>1265-4906</issn><eissn>1248-9204</eissn><abstract>Introduction
The purpose of this study was to evaluate the acute fixation strength of fibrin sealant as an alternative fixation method for laparoscopic ventral hernia repair (LVHR) when utilized with absorbable and nonabsorbable barrier meshes.
Methods
Representative mesh types for LVHR included one nonabsorbable barrier mesh (Bard
®
Composix™) and three absorbable barrier meshes (Sepramesh™, Proceed™, and Parietex™ Composite Mesh). Macroporous polypropylene mesh (Prolite Ultra™) served as a control. An associated pilot study demonstrated that acute fixation was not achieved with C-Qur™ or Dualmesh
®
, thus these meshes were not subjected to further analysis. Two fibrin sealants varying in thrombin concentration (TISSEEL™ 500 IU/ml or ARTISS™ 4 IU/ml) were each utilized to secure a 3 × 4 cm piece of mesh to the peritoneal surface of harvested abdominal wall from New Zealand white rabbits. Ten samples were prepared for each mesh and fibrin sealant combination. The resulting mesh-tissue interface (3 × 3 cm) underwent lap shear testing at a rate of 0.42 mm/s using a tensiometer (Instron 5542, Norwood, MA). The maximum load sustained by the construct was recorded as the acute fixation strength in units of Newtons (N). Data are given as means ± SEM. Statistical significance (
P
< 0.05) was determined using a two-way ANOVA and Bonferroni post-test.
Results
There was no significant difference (
P
> 0.05) in the acute fixation strength achieved by ARTISS™ versus TISSEEL™ with Composix™, Sepramesh™, Proceed™, and Parietex™ Composite Mesh. However, Prolite Ultra™ fixed with ARTISS™ (7.099 ± 1.01 N) had a significantly higher tensile strength (
P
< 0.001) than Prolite Ultra™ fixed with TISSEEL™ (3.405 ± 0.72 N). Among meshes fixed with TISSEEL™, Parietex™ Composite (3.936 ± 0.73 N) was significantly stronger than Sepramesh™ (1.760 ± 0.33 N) (
P
< 0.05).
Conclusions
Acute fixation strength is equivalent for TISSEEL™ and ARTISS™ fibrin sealants for selected nonabsorbable (Composix™) and absorbable barrier-coated (Sepramesh™, Proceed™, and Parietex™ Composite Mesh) meshes. Previous evaluations in this model indicated fibrin sealant alone did not appear to be a suitable method of fixation with C-Qur™ or DualMesh
®
against the peritoneum. Long-term evaluation is needed to evaluate the efficacy of this method of fixation using absorbable and nonabsorbable barrier-coated meshes in a model of LVHR.</abstract><cop>Paris</cop><pub>Springer-Verlag</pub><pmid>20454989</pmid><doi>10.1007/s10029-010-0670-3</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1265-4906 |
| ispartof | Hernia : the journal of hernias and abdominal wall surgery, 2010-10, Vol.14 (5), p.505-509 |
| issn | 1265-4906 1248-9204 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Animals Coated Materials, Biocompatible Disease Models, Animal Fibrin Tissue Adhesive Hernia, Ventral - surgery Laparoscopy - methods Materials Testing - methods Medicine Medicine & Public Health Original Article Polypropylenes Polytetrafluoroethylene Prosthesis Design Rabbits Surgical Mesh Tensile Strength |
| title | Evaluation of acute fixation strength of absorbable and nonabsorbable barrier coated mesh secured with fibrin sealant |
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