Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

Local Ca 2+ signaling occurring within nanometers of voltage-gated Ca 2+ (Cav) channels is crucial for CNS function, yet the molecular composition of Cav channel nano-environments is largely unresolved. Here, we used a proteomic strategy combining knockout-controlled multiepitope affinity purificati...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-08, Vol.107 (34), p.14950-14957
Hauptverfasser:	Müller, Catrin Swantje, Haupt, Alexander, Bildl, Wolfgang, Schindler, Jens, Knaus, Hans-Günther, Meissner, Marcel, Rammner, Burkhard, Striessnig, Jörg, Flockerzi, Veit, Fakler, Bernd, Schulte, Uwe, Catterall, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological Sciences Brain Brain - metabolism Calcium Calcium (intracellular) Calcium channels Calcium channels (voltage-gated) Calcium Channels - chemistry Calcium Channels - deficiency Calcium Channels - genetics Calcium Channels - metabolism Calcium Signaling Calcium signalling Cell membranes Cells Central nervous system Channel gating Cytoskeleton In Vitro Techniques Intracellular signalling Mice Mice, Knockout Models, Molecular Molecular Sequence Data Molecular structure Multiprotein Complexes Neurons Neuroscience Protein Stability Protein Subunits Proteome Proteomes Proteomics Proteomics - methods Rats Rodents Signal transduction Solubilization Synaptic vesicles
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