$Dose/dense metronomic chemotherapy with fractioned cisplatin and oral daily etoposide enhances the anti-angiogenic effects of bevacizumab and has strong antitumor activity in advanced non-small-cell-lung cancer patients$

Dose/dense metronomic chemotherapy with fractioned cisplatin and oral daily etoposide enhances the anti-angiogenic effects of bevacizumab and has strong antitumor activity in advanced non-small-cell-lung cancer patients

We designed a translational clinical trial to investigate whether a dose/dense chemotherapy regimen is able to enhance in patients with non-small-cell-lung-cancer (NSCLC) the anti-angiogenic effects of bevacizumab, a murine/human monoclonal antibody to the vasculo-endothelial-growth-factor (VEGF). W...

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Veröffentlicht in:	Cancer biology & therapy 2010-05, Vol.9 (9), p.685-693
Hauptverfasser:	Correale, Pierpaolo, Remondo, Cinzia, Carbone, Salvatore Francesco, Ricci, Veronica, Migali, Cristina, Martellucci, Ignazio, Licchetta, Antonella, Addeo, Raffaele, Volterrani, Luca, Gotti, Giuseppe, Rotundo, Maria Saveria, Tassone, Pierfrancesco, Sperlongano, Pasquale, Abbruzzese, Alberto, Caraglia, Michele, Tagliaferri, Pierosandro, Francini, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - drug therapy Adenocarcinoma - secondary Administration, Oral Adult Aged Aged, 80 and over Angiopoietin-1 - blood Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - secondary Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - secondary Cisplatin - administration & dosage Drug Synergism Enzyme-Linked Immunosorbent Assay Etoposide - administration & dosage Female Humans Lung Neoplasms - blood Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Maximum Tolerated Dose Middle Aged Prospective Studies Survival Rate Thrombospondins - blood Treatment Outcome Vascular Endothelial Growth Factor A - blood
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