Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons
Several mRNAs are known to be targeted to dendrites in hippocampal neurons. In this study, we show that brain-derived neurotrophic factor (BDNF) mRNA has two distinct cis-acting dendritic targeting elements in the short 3′ untranslated region (UTR): a constitutive element and an activity-dependent o...
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| Veröffentlicht in: | FEBS letters 2010-08, Vol.584 (15), p.3424-3430 |
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| description | Several mRNAs are known to be targeted to dendrites in hippocampal neurons. In this study, we show that brain-derived neurotrophic factor (BDNF) mRNA has two distinct
cis-acting dendritic targeting elements in the short 3′ untranslated region (UTR): a constitutive element and an activity-dependent one. Moreover, deletion of serial cytoplasmic polyadenylation element (CPE)-like sequences in the short 3′UTR suppressed both constitutive and activity-dependent dendritic targeting. In addition to the interaction with cytoplasmic polyadenylation element binding protein-1 (CPEB-1), depolarization enhanced CPEB-1 recruitment to the activity-dependent targeting element. These results suggest that CPE-like sequences are involved in the activity-dependent as well as constitutive dendritic targeting of BDNF mRNA. |
| doi_str_mv | 10.1016/j.febslet.2010.06.040 |
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cis-acting dendritic targeting elements in the short 3′ untranslated region (UTR): a constitutive element and an activity-dependent one. Moreover, deletion of serial cytoplasmic polyadenylation element (CPE)-like sequences in the short 3′UTR suppressed both constitutive and activity-dependent dendritic targeting. In addition to the interaction with cytoplasmic polyadenylation element binding protein-1 (CPEB-1), depolarization enhanced CPEB-1 recruitment to the activity-dependent targeting element. These results suggest that CPE-like sequences are involved in the activity-dependent as well as constitutive dendritic targeting of BDNF mRNA.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2010.06.040</identifier><identifier>PMID: 20603120</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>3' Untranslated Regions - genetics ; Animals ; Base Sequence ; BDNF ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; CPE ; CPEB-1 ; Cytoplasm - drug effects ; Cytoplasm - genetics ; Cytoplasmic polyadenylation element ; cytoplasmic polyadenylation element binding protein-1 ; Dendrites - drug effects ; Dendrites - metabolism ; dendritic targeting element ; DTE ; Gene Expression Regulation - drug effects ; Genes, Reporter - genetics ; Genetic Vectors - genetics ; Hippocampal neurons ; Hippocampus - cytology ; Membrane Potentials - drug effects ; Mice ; Molecular Sequence Data ; mRNA Cleavage and Polyadenylation Factors - genetics ; mRNA Cleavage and Polyadenylation Factors - metabolism ; mRNA targeting ; Polyadenylation - genetics ; Potassium Chloride - pharmacology ; Protein Binding - drug effects ; Rats ; Rats, Wistar ; Regulatory Sequences, Ribonucleic Acid - genetics ; RNA Transport - drug effects ; RNA Transport - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism ; untranslated region ; UTR</subject><ispartof>FEBS letters, 2010-08, Vol.584 (15), p.3424-3430</ispartof><rights>2010 Federation of European Biochemical Societies</rights><rights>FEBS Letters 584 (2010) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5759-5a176cc0eb22ef0d8478aed4a6cca5d25fc2663cfdd0136142d01342c38704803</citedby><cites>FETCH-LOGICAL-c5759-5a176cc0eb22ef0d8478aed4a6cca5d25fc2663cfdd0136142d01342c38704803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2010.06.040$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579310005399$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20603120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oe, Souichi</creatorcontrib><creatorcontrib>Yoneda, Yoshihiro</creatorcontrib><title>Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Several mRNAs are known to be targeted to dendrites in hippocampal neurons. In this study, we show that brain-derived neurotrophic factor (BDNF) mRNA has two distinct
cis-acting dendritic targeting elements in the short 3′ untranslated region (UTR): a constitutive element and an activity-dependent one. Moreover, deletion of serial cytoplasmic polyadenylation element (CPE)-like sequences in the short 3′UTR suppressed both constitutive and activity-dependent dendritic targeting. In addition to the interaction with cytoplasmic polyadenylation element binding protein-1 (CPEB-1), depolarization enhanced CPEB-1 recruitment to the activity-dependent targeting element. These results suggest that CPE-like sequences are involved in the activity-dependent as well as constitutive dendritic targeting of BDNF mRNA.</description><subject>3' Untranslated Regions - genetics</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>BDNF</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>CPE</subject><subject>CPEB-1</subject><subject>Cytoplasm - drug effects</subject><subject>Cytoplasm - genetics</subject><subject>Cytoplasmic polyadenylation element</subject><subject>cytoplasmic polyadenylation element binding protein-1</subject><subject>Dendrites - drug effects</subject><subject>Dendrites - metabolism</subject><subject>dendritic targeting element</subject><subject>DTE</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes, Reporter - genetics</subject><subject>Genetic Vectors - genetics</subject><subject>Hippocampal neurons</subject><subject>Hippocampus - cytology</subject><subject>Membrane Potentials - drug effects</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>mRNA Cleavage and Polyadenylation Factors - genetics</subject><subject>mRNA Cleavage and Polyadenylation Factors - metabolism</subject><subject>mRNA targeting</subject><subject>Polyadenylation - genetics</subject><subject>Potassium Chloride - pharmacology</subject><subject>Protein Binding - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regulatory Sequences, Ribonucleic Acid - genetics</subject><subject>RNA Transport - drug effects</subject><subject>RNA Transport - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>untranslated region</subject><subject>UTR</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEURi0EomnhJ4C8g80Ev8bjWaE2NBSpKhKPteXYd4qDZzzYk6Dw6-tRAktgde2rcz8_DkIvKFlSQuWb7bKDTQ4wLRkpPSKXRJBHaEFVwysupHqMFoRQUdVNy8_Qec5bUvaKtk_RGSOScMrIAv1aHaY4BpN7b_EYw8E4GA7BTD4OGAL0MExV8N8BZ_ixg8FCxiYB9sM-hj24ssBlwiU_lYDJpHuY_HCPY4ev3t2tcf_p7nJmvvlxjNb0owl4gF2KQ36GnnQmZHh-qhfo6_r6y-qmuv34_sPq8raydVO3VW1oI60lsGEMOuKUaJQBJ0xpmtqxurNMSm475wjlkgo2V8EsVw0RivAL9OqYO6ZYnpAn3ftsIQQzQNxl3QjVKiGZKuTrv5KUNlTJhtdzaH1EbYo5J-j0mHxv0kFTomdBeqtPgvQsSBOpi6Ay9_J0xG7Tg_sz9dtIAW6OwE8f4PB_qXp9fcU-z7Zn2bR4rnnblqi3xygov7v3kHS2flbofAI7aRf9P277ABLrus0</recordid><startdate>20100804</startdate><enddate>20100804</enddate><creator>Oe, Souichi</creator><creator>Yoneda, Yoshihiro</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20100804</creationdate><title>Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons</title><author>Oe, Souichi ; Yoneda, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5759-5a176cc0eb22ef0d8478aed4a6cca5d25fc2663cfdd0136142d01342c38704803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>BDNF</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>CPE</topic><topic>CPEB-1</topic><topic>Cytoplasm - drug effects</topic><topic>Cytoplasm - genetics</topic><topic>Cytoplasmic polyadenylation element</topic><topic>cytoplasmic polyadenylation element binding protein-1</topic><topic>Dendrites - drug effects</topic><topic>Dendrites - metabolism</topic><topic>dendritic targeting element</topic><topic>DTE</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes, Reporter - genetics</topic><topic>Genetic Vectors - genetics</topic><topic>Hippocampal neurons</topic><topic>Hippocampus - cytology</topic><topic>Membrane Potentials - drug effects</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>mRNA Cleavage and Polyadenylation Factors - genetics</topic><topic>mRNA Cleavage and Polyadenylation Factors - metabolism</topic><topic>mRNA targeting</topic><topic>Polyadenylation - genetics</topic><topic>Potassium Chloride - pharmacology</topic><topic>Protein Binding - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regulatory Sequences, Ribonucleic Acid - genetics</topic><topic>RNA Transport - drug effects</topic><topic>RNA Transport - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>untranslated region</topic><topic>UTR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oe, Souichi</creatorcontrib><creatorcontrib>Yoneda, Yoshihiro</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oe, Souichi</au><au>Yoneda, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2010-08-04</date><risdate>2010</risdate><volume>584</volume><issue>15</issue><spage>3424</spage><epage>3430</epage><pages>3424-3430</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Several mRNAs are known to be targeted to dendrites in hippocampal neurons. In this study, we show that brain-derived neurotrophic factor (BDNF) mRNA has two distinct
cis-acting dendritic targeting elements in the short 3′ untranslated region (UTR): a constitutive element and an activity-dependent one. Moreover, deletion of serial cytoplasmic polyadenylation element (CPE)-like sequences in the short 3′UTR suppressed both constitutive and activity-dependent dendritic targeting. In addition to the interaction with cytoplasmic polyadenylation element binding protein-1 (CPEB-1), depolarization enhanced CPEB-1 recruitment to the activity-dependent targeting element. These results suggest that CPE-like sequences are involved in the activity-dependent as well as constitutive dendritic targeting of BDNF mRNA.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>20603120</pmid><doi>10.1016/j.febslet.2010.06.040</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated Regions - genetics Animals Base Sequence BDNF Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism CPE CPEB-1 Cytoplasm - drug effects Cytoplasm - genetics Cytoplasmic polyadenylation element cytoplasmic polyadenylation element binding protein-1 Dendrites - drug effects Dendrites - metabolism dendritic targeting element DTE Gene Expression Regulation - drug effects Genes, Reporter - genetics Genetic Vectors - genetics Hippocampal neurons Hippocampus - cytology Membrane Potentials - drug effects Mice Molecular Sequence Data mRNA Cleavage and Polyadenylation Factors - genetics mRNA Cleavage and Polyadenylation Factors - metabolism mRNA targeting Polyadenylation - genetics Potassium Chloride - pharmacology Protein Binding - drug effects Rats Rats, Wistar Regulatory Sequences, Ribonucleic Acid - genetics RNA Transport - drug effects RNA Transport - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - genetics Transcription Factors - metabolism untranslated region UTR |
| title | Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons |
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