Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema

Chronic airway inflammation is a characteristic feature of destructive cigarette smoking (CS)-induced lung disease, particularly in patients with emphysema. Celecoxib, a specific cyclooxygenase-2 (COX-2) inhibitor, is widely used to treat inflammation. However, the exact mechanisms underlying this d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2010-08, Vol.299 (2), p.L184-L191
Hauptverfasser:	Roh, Gu Seob, Yi, Chin-ok, Cho, Yu Ji, Jeon, Byeong Tak, Nizamudtinova, Irina Tsoy, Kim, Hye Jung, Kim, Jin Hyun, Oh, Yeon-Mok, Huh, Jin Won, Lee, Ji-Hyun, Hwang, Young Sil, Lee, Sang Do, Lee, Jong Deog
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Animals Anti-Inflammatory Agents - pharmacology Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Celecoxib Cell Line Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dinoprostone - metabolism Effects Gene expression I-kappa B Proteins - metabolism Inflammation - pathology Lung diseases Macrophages - drug effects Macrophages - metabolism Male Mice NF-kappa B - metabolism NF-KappaB Inhibitor alpha Nitric Oxide - biosynthesis Nitric Oxide - blood Nitric Oxide Synthase Type II - antagonists & inhibitors Phosphorylation Pulmonary Alveoli - pathology Pulmonary Emphysema - drug therapy Pulmonary Emphysema - etiology Pulmonary Emphysema - pathology Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Rodents Smoking Smoking - adverse effects Sulfonamides - pharmacology Tissues
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!