Higher skeletal muscular metabolic reserve capacity in COPD patients than healthy subjects
We investigated the interaction between skeletal muscle exercise capacity and central restrictions using exercise modalities, which recruit differing levels of muscle mass in eight patients chronic obstructive lung disease (COPD) (FEV1% of predicted; 35 [SE 4%]) and eight healthy controls. Subjects...
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| Veröffentlicht in: | Scandinavian journal of medicine & science in sports 2009-12, Vol.19 (6), p.857-864 |
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| container_title | Scandinavian journal of medicine & science in sports |
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| creator | Rud, B. Christensen, C. C. Ryg, M. Edvardsen, A. Skumlien, S. Hallén, J. |
| description | We investigated the interaction between skeletal muscle exercise capacity and central restrictions using exercise modalities, which recruit differing levels of muscle mass in eight patients chronic obstructive lung disease (COPD) (FEV1% of predicted; 35 [SE 4%]) and eight healthy controls. Subjects performed conventional bicycling, two‐leg knee extensor (2‐KE) and single‐leg knee extensor (1‐KE) exercises. Maximal values for pulmonary V̇O2 (VO2max), power output, blood lactate, heart rate, blood pressure, and arterial oxygen saturation of hemoglobin were registered. VO2max in controls was 2453 (210), 1468 (124), and 976 (76) mL/min during bicycling, 2‐KE and 1‐KE, respectively. The COPD patients achieved 48% (P |
| doi_str_mv | 10.1111/j.1600-0838.2008.00846.x |
| format | Article |
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C. ; Ryg, M. ; Edvardsen, A. ; Skumlien, S. ; Hallén, J.</creator><creatorcontrib>Rud, B. ; Christensen, C. C. ; Ryg, M. ; Edvardsen, A. ; Skumlien, S. ; Hallén, J.</creatorcontrib><description>We investigated the interaction between skeletal muscle exercise capacity and central restrictions using exercise modalities, which recruit differing levels of muscle mass in eight patients chronic obstructive lung disease (COPD) (FEV1% of predicted; 35 [SE 4%]) and eight healthy controls. Subjects performed conventional bicycling, two‐leg knee extensor (2‐KE) and single‐leg knee extensor (1‐KE) exercises. Maximal values for pulmonary V̇O2 (VO2max), power output, blood lactate, heart rate, blood pressure, and arterial oxygen saturation of hemoglobin were registered. VO2max in controls was 2453 (210), 1468 (124), and 976 (76) mL/min during bicycling, 2‐KE and 1‐KE, respectively. The COPD patients achieved 48% (P<0.05), 62% (P<0.05), and 81% (P=0.10) of the control values. The mass‐specific VO2max (VO2max/exercising muscle mass) during 1‐KE was 345 (25) and 263 (30) mL/kg/min (P<0.05) in controls and COPD patients, respectively. During 2‐KE the controls and COPD patients achieved 85% (4%) and 67% (5%) (P=0.06) of the mass‐specific V̇O2 during 1‐KE, while during bicycling they achieved 31% (2%) and 17% (1%) (P<0.05), respectively. The COPD patients have central restrictions when exercising with a relatively small muscle mass (2‐KE) and have a higher muscular metabolic reserve capacity than controls during whole body exercise.</description><identifier>ISSN: 0905-7188</identifier><identifier>EISSN: 1600-0838</identifier><identifier>DOI: 10.1111/j.1600-0838.2008.00846.x</identifier><identifier>PMID: 19508654</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Blood Pressure - physiology ; central limitations ; Chronic obstructive pulmonary disease ; Exercise - physiology ; Exercise Tolerance - physiology ; Female ; Health ; Heart Rate - physiology ; Humans ; Lactic Acid - blood ; lung disease ; Male ; Metabolic disorders ; Middle Aged ; Muscle, Skeletal - metabolism ; muscular efficiency ; muscular metabolic capacity ; Norway ; Oxygen Consumption - physiology ; Patients ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Gas Exchange - physiology ; Skeletal system</subject><ispartof>Scandinavian journal of medicine & science in sports, 2009-12, Vol.19 (6), p.857-864</ispartof><rights>2009 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4326-ad82f01209bb8da1a78c22e3b57957d9573688fd7ba3077e08f741c5825441d33</citedby><cites>FETCH-LOGICAL-c4326-ad82f01209bb8da1a78c22e3b57957d9573688fd7ba3077e08f741c5825441d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0838.2008.00846.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0838.2008.00846.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19508654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rud, B.</creatorcontrib><creatorcontrib>Christensen, C. C.</creatorcontrib><creatorcontrib>Ryg, M.</creatorcontrib><creatorcontrib>Edvardsen, A.</creatorcontrib><creatorcontrib>Skumlien, S.</creatorcontrib><creatorcontrib>Hallén, J.</creatorcontrib><title>Higher skeletal muscular metabolic reserve capacity in COPD patients than healthy subjects</title><title>Scandinavian journal of medicine & science in sports</title><addtitle>Scand J Med Sci Sports</addtitle><description>We investigated the interaction between skeletal muscle exercise capacity and central restrictions using exercise modalities, which recruit differing levels of muscle mass in eight patients chronic obstructive lung disease (COPD) (FEV1% of predicted; 35 [SE 4%]) and eight healthy controls. Subjects performed conventional bicycling, two‐leg knee extensor (2‐KE) and single‐leg knee extensor (1‐KE) exercises. Maximal values for pulmonary V̇O2 (VO2max), power output, blood lactate, heart rate, blood pressure, and arterial oxygen saturation of hemoglobin were registered. VO2max in controls was 2453 (210), 1468 (124), and 976 (76) mL/min during bicycling, 2‐KE and 1‐KE, respectively. The COPD patients achieved 48% (P<0.05), 62% (P<0.05), and 81% (P=0.10) of the control values. The mass‐specific VO2max (VO2max/exercising muscle mass) during 1‐KE was 345 (25) and 263 (30) mL/kg/min (P<0.05) in controls and COPD patients, respectively. During 2‐KE the controls and COPD patients achieved 85% (4%) and 67% (5%) (P=0.06) of the mass‐specific V̇O2 during 1‐KE, while during bicycling they achieved 31% (2%) and 17% (1%) (P<0.05), respectively. The COPD patients have central restrictions when exercising with a relatively small muscle mass (2‐KE) and have a higher muscular metabolic reserve capacity than controls during whole body exercise.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Pressure - physiology</subject><subject>central limitations</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Exercise - physiology</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Health</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Lactic Acid - blood</subject><subject>lung disease</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - metabolism</subject><subject>muscular efficiency</subject><subject>muscular metabolic capacity</subject><subject>Norway</subject><subject>Oxygen Consumption - physiology</subject><subject>Patients</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Gas Exchange - physiology</subject><subject>Skeletal system</subject><issn>0905-7188</issn><issn>1600-0838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF2L1DAUhoMo7rj6FyR441VrPpsUvJFRZ4RdV1zFxZuQpqdOu2k7JqnO_Hs7O8MKXhk4hJDnfTk8CGFKcjqfV11OC0IyornOGSE6n0cU-e4BWtx_PEQLUhKZKar1GXoSY0cIVaWQj9EZLSXRhRQL9H3d_thAwPEWPCTrcT9FN3kbcD8_q9G3DgeIEH4BdnZrXZv2uB3w8urTW7y1qYUhRZw2dsAbsD5t9jhOVQcuxafoUWN9hGen-xx9ff_uy3KdXVytPizfXGROcFZkttasIZSRsqp0balV2jEGvJKqlKqehxdaN7WqLCdKAdGNEtRJzaQQtOb8HL089m7D-HOCmEzfRgfe2wHGKRoldKk5L8RMvviH7MYpDPNyhlFBJJWimCF9hFwYYwzQmG1oexv2hhJzsG86c5BsDpLNwb65s292c_T5qX-qeqj_Bk-6Z-D1Efjdetj_d7G5vrzWd6tlx3gbE-zu4zbcmkJxJc23jysjPq-Zulldmhv-B-QUoSY</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Rud, B.</creator><creator>Christensen, C. C.</creator><creator>Ryg, M.</creator><creator>Edvardsen, A.</creator><creator>Skumlien, S.</creator><creator>Hallén, J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Higher skeletal muscular metabolic reserve capacity in COPD patients than healthy subjects</title><author>Rud, B. ; Christensen, C. C. ; Ryg, M. ; Edvardsen, A. ; Skumlien, S. ; Hallén, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4326-ad82f01209bb8da1a78c22e3b57957d9573688fd7ba3077e08f741c5825441d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Pressure - physiology</topic><topic>central limitations</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Exercise - physiology</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Health</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Lactic Acid - blood</topic><topic>lung disease</topic><topic>Male</topic><topic>Metabolic disorders</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - metabolism</topic><topic>muscular efficiency</topic><topic>muscular metabolic capacity</topic><topic>Norway</topic><topic>Oxygen Consumption - physiology</topic><topic>Patients</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Gas Exchange - physiology</topic><topic>Skeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rud, B.</creatorcontrib><creatorcontrib>Christensen, C. 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C.</au><au>Ryg, M.</au><au>Edvardsen, A.</au><au>Skumlien, S.</au><au>Hallén, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher skeletal muscular metabolic reserve capacity in COPD patients than healthy subjects</atitle><jtitle>Scandinavian journal of medicine & science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2009-12</date><risdate>2009</risdate><volume>19</volume><issue>6</issue><spage>857</spage><epage>864</epage><pages>857-864</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract>We investigated the interaction between skeletal muscle exercise capacity and central restrictions using exercise modalities, which recruit differing levels of muscle mass in eight patients chronic obstructive lung disease (COPD) (FEV1% of predicted; 35 [SE 4%]) and eight healthy controls. Subjects performed conventional bicycling, two‐leg knee extensor (2‐KE) and single‐leg knee extensor (1‐KE) exercises. Maximal values for pulmonary V̇O2 (VO2max), power output, blood lactate, heart rate, blood pressure, and arterial oxygen saturation of hemoglobin were registered. VO2max in controls was 2453 (210), 1468 (124), and 976 (76) mL/min during bicycling, 2‐KE and 1‐KE, respectively. The COPD patients achieved 48% (P<0.05), 62% (P<0.05), and 81% (P=0.10) of the control values. The mass‐specific VO2max (VO2max/exercising muscle mass) during 1‐KE was 345 (25) and 263 (30) mL/kg/min (P<0.05) in controls and COPD patients, respectively. During 2‐KE the controls and COPD patients achieved 85% (4%) and 67% (5%) (P=0.06) of the mass‐specific V̇O2 during 1‐KE, while during bicycling they achieved 31% (2%) and 17% (1%) (P<0.05), respectively. The COPD patients have central restrictions when exercising with a relatively small muscle mass (2‐KE) and have a higher muscular metabolic reserve capacity than controls during whole body exercise.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19508654</pmid><doi>10.1111/j.1600-0838.2008.00846.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Blood Pressure - physiology central limitations Chronic obstructive pulmonary disease Exercise - physiology Exercise Tolerance - physiology Female Health Heart Rate - physiology Humans Lactic Acid - blood lung disease Male Metabolic disorders Middle Aged Muscle, Skeletal - metabolism muscular efficiency muscular metabolic capacity Norway Oxygen Consumption - physiology Patients Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Gas Exchange - physiology Skeletal system |
| title | Higher skeletal muscular metabolic reserve capacity in COPD patients than healthy subjects |
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