trans-Resveratrol Inhibits Hyperglycemia-Induced Inflammation and Connexin Downregulation in Retinal Pigment Epithelial Cells

The purpose of this study was to determine the inhibitory activity of trans-resveratrol against hyperglycemia-induced inflammation and degradation of gap junction intercellular communication in retinal pigment epithelial cells. Retinal (ARPE-19) cells were incubated with 5.5 mM glucose, 5.5 mM gluco...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2010-07, Vol.58 (14), p.8246-8252
Hauptverfasser:	Losso, Jack N, Truax, Robert E, Richard, Gerald
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenic factors Bioactive Constituents Biological and medical sciences biomarkers cell communication Cell Line Connexin 43 - genetics Connexin 43 - immunology connexins Diabetic Retinopathy - drug therapy Diabetic Retinopathy - etiology Diabetic Retinopathy - immunology Down-Regulation - drug effects epithelial cells Food industries Fundamental and applied biological sciences. Psychology gap junctions Gap Junctions - drug effects Gap Junctions - immunology human diseases human nutrition Humans hyperglycemia Hyperglycemia - complications Hyperglycemia - drug therapy Hyperglycemia - immunology inflammation interleukin-6 Interleukin-6 - immunology interleukin-8 Interleukin-8 - immunology oxidative stress phytochemicals prostaglandin synthase protein kinase C protein synthesis resveratrol retina Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - immunology Stilbenes - pharmacology transforming growth factor beta Transforming Growth Factor beta1 - immunology vascular endothelial growth factors viability
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