Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia
Evidence for white matter abnormalities in patients with schizophrenia is increasing. Decreased fractional anisotropy (FA) in interhemispheric commissural fibers as well as long-ranging fronto-parietal association fibers belongs to the most frequent findings. The present study used tract-based spati...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2010-08, Vol.260 (5), p.419-426 |
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| creator | Koch, Kathrin Wagner, Gerd Dahnke, Robert Schachtzabel, Claudia Schultz, Christoph Roebel, Martin Güllmar, Daniel Reichenbach, Jürgen R. Sauer, Heinrich Schlösser, Ralf G. M. |
| description | Evidence for white matter abnormalities in patients with schizophrenia is increasing. Decreased fractional anisotropy (FA) in interhemispheric commissural fibers as well as long-ranging fronto-parietal association fibers belongs to the most frequent findings. The present study used tract-based spatial statistics to investigate white matter integrity in 35 patients with schizophrenia and 35 healthy volunteers. We found that patients exhibited significantly decreased FA relative to healthy subjects in the corpus callosum, the cerebral peduncle, the left inferior fronto-occipital fasciculus, the anterior thalamic radiation, the right posterior corona radiata, the middle cerebellar peduncle, and the right superior longitudinal fasciculus. Increased FA was detectable in the inferior sections of the corticopontine-cerebellar circuit. Present data indicate extended cortical-subcortical alterations of white matter integrity in schizophrenia using advanced data analysis strategies. They corroborate preceding findings of white matter structural deficits in mainly long-ranging association fibers and provide first evidence for neuroplastic changes in terms of an increased directionality in more inferior fiber tracts. |
| doi_str_mv | 10.1007/s00406-009-0087-0 |
| format | Article |
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Increased FA was detectable in the inferior sections of the corticopontine-cerebellar circuit. Present data indicate extended cortical-subcortical alterations of white matter integrity in schizophrenia using advanced data analysis strategies. 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M.</creatorcontrib><title>Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Evidence for white matter abnormalities in patients with schizophrenia is increasing. Decreased fractional anisotropy (FA) in interhemispheric commissural fibers as well as long-ranging fronto-parietal association fibers belongs to the most frequent findings. The present study used tract-based spatial statistics to investigate white matter integrity in 35 patients with schizophrenia and 35 healthy volunteers. 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They corroborate preceding findings of white matter structural deficits in mainly long-ranging association fibers and provide first evidence for neuroplastic changes in terms of an increased directionality in more inferior fiber tracts.</description><subject>Adult</subject><subject>Anisotropy</subject><subject>Brain Mapping</subject><subject>Cerebellum - pathology</subject><subject>Cerebral Cortex - pathology</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Neural Pathways - pathology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Pons - pathology</subject><subject>Psychiatry</subject><subject>Schizophrenia - pathology</subject><subject>Young Adult</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kF1LwzAUhoMobk5_gDdSvPGqek6TNs2lzE8YeKPgXeiydMvYmpqkyPz1pnQwEAyEXOR533N4CLlEuEUAfucBGBQpgIi35CkckTEyStOSCTwmYxAMUqSUjciZ92sAwDyDUzJCITAXpRiTzwfjXdcGvUi-VyboZFuFoF1imqCXzoRdYutEWReMsq1tgml0qrTTc73ZVC5RxqnOBLeLgcSrlfmx7crpxlTn5KSuNl5f7N8J-Xh6fJ--pLO359fp_SxVlENIEVhRLDhkXKFQWEKVY8kFyyivmShof1TBFpxT1CjyOa9zwSiyCrAAyumE3Ay9rbNfnfZBbo1X_XaNtp2XnJWipFhkkbz-Q65t55q4XIQQRMZi4YTgAClnvXe6lq0z28rtJILspctBuozSZS9d9pmrfXE33-rFIbG3HIFsAHz8apbaHSb_3_oLd0-LLw</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Koch, Kathrin</creator><creator>Wagner, Gerd</creator><creator>Dahnke, Robert</creator><creator>Schachtzabel, Claudia</creator><creator>Schultz, Christoph</creator><creator>Roebel, Martin</creator><creator>Güllmar, Daniel</creator><creator>Reichenbach, Jürgen R.</creator><creator>Sauer, Heinrich</creator><creator>Schlösser, Ralf G. 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| ispartof | European archives of psychiatry and clinical neuroscience, 2010-08, Vol.260 (5), p.419-426 |
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| subjects | Adult Anisotropy Brain Mapping Cerebellum - pathology Cerebral Cortex - pathology Diffusion Magnetic Resonance Imaging Female Humans Male Medicine Medicine & Public Health Nerve Fibers, Myelinated - physiology Neural Pathways - pathology Neurosciences Original Paper Pons - pathology Psychiatry Schizophrenia - pathology Young Adult |
| title | Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia |
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