Plasmonic Nanoparticle Dimers for Optical Sensing of DNA in Complex Media

We introduce a new sensing modality based on the actuation of discrete gold nanoparticle dimers. Binding of the target DNA leads to a geometrical extension of the dimer, thereby yielding a spectral blue shift in the hybridized plasmon mode as detected by single nanostructure scattering spectroscopy....

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Veröffentlicht in:	Journal of the American Chemical Society 2010-07, Vol.132 (28), p.9600-9601
Hauptverfasser:	Chen, Jennifer I. L, Chen, Yeechi, Ginger, David S
Format:	Artikel
Sprache:	eng
Schlagworte:	Dimerization DNA - analysis Gold Metal Nanoparticles Spectrum Analysis - methods
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creator	Chen, Jennifer I. L Chen, Yeechi Ginger, David S
description	We introduce a new sensing modality based on the actuation of discrete gold nanoparticle dimers. Binding of the target DNA leads to a geometrical extension of the dimer, thereby yielding a spectral blue shift in the hybridized plasmon mode as detected by single nanostructure scattering spectroscopy. The magnitude and opposite direction of this shift enabled us to spectroscopically distinguish the target from nonspecific binding and to detect the target in complex media like serum.
doi_str_mv	10.1021/ja103240g
format	Article
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L</creatorcontrib><creatorcontrib>Chen, Yeechi</creatorcontrib><creatorcontrib>Ginger, David S</creatorcontrib><title>Plasmonic Nanoparticle Dimers for Optical Sensing of DNA in Complex Media</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>We introduce a new sensing modality based on the actuation of discrete gold nanoparticle dimers. Binding of the target DNA leads to a geometrical extension of the dimer, thereby yielding a spectral blue shift in the hybridized plasmon mode as detected by single nanostructure scattering spectroscopy. The magnitude and opposite direction of this shift enabled us to spectroscopically distinguish the target from nonspecific binding and to detect the target in complex media like serum.</description><subject>Dimerization</subject><subject>DNA - analysis</subject><subject>Gold</subject><subject>Metal Nanoparticles</subject><subject>Spectrum Analysis - methods</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1Lw0AQBuBFFFurB_-A7EXEQ3T2K9keS-tHobaCeg6bzW5JSbJxtwH996609uRpmOHhhXkRuiRwR4CS-40iwCiH9REaEkEhEYSmx2gIADTJZMoG6CyETVw5leQUDSgIySRjQzR_rVVoXFtpvFSt65TfVro2eFY1xgdsncerLp5Ujd9MG6p2jZ3Fs-UEVy2euqarzRd-MWWlztGJVXUwF_s5Qh-PD-_T52SxeppPJ4tEMQnbpEgNcCWAcK2ESq0oqC4ZsSYr9DiL9zEHS4XOTGaF0Kzk3DIqIyvGBIqUjdDNLrfz7rM3YZs3VdCmrlVrXB_yjMuxJCBElLc7qb0LwRubd75qlP_OCeS_xeWH4qK92qf2RWPKg_xrKoLrHVA65BvX-zY--U_QDw8fcqA</recordid><startdate>20100721</startdate><enddate>20100721</enddate><creator>Chen, Jennifer I. 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subjects	Dimerization DNA - analysis Gold Metal Nanoparticles Spectrum Analysis - methods
title	Plasmonic Nanoparticle Dimers for Optical Sensing of DNA in Complex Media
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