Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights

An enantioselective preparation of 2,5-cis-disubstituted pyrrolidines has been achieved via a dynamic kinetic asymmetric transformation (DyKAT) of racemic donor−acceptor cyclopropanes and (E)-aldimines. Mechanistic studies suggest that isomerization of the aldimine or resultant iminium to the Z geom...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-07, Vol.132 (28), p.9688-9692
Hauptverfasser:	Parsons, Andrew T, Smith, Austin G, Neel, Andrew J, Johnson, Jeffrey S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclopropanes - chemistry Kinetics Magnetic Resonance Spectroscopy Pyrrolidines - chemical synthesis Pyrrolidines - chemistry Stereoisomerism
Online-Zugang:	Volltext
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