(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT6 Receptor

5-HT6 receptors are exclusively localized in the CNS and have high affinity with many psychotropic agents. Though the role of this receptor in many CNS diseases is widely anticipated, lack of definite progress in the development of 5-HT6 receptor-oriented drugs indicates a need for further discoveri...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-07, Vol.53 (14), p.5186-5196
Hauptverfasser:	Ivachtchenko, Alexandre V, Dmitriev, Dmitri E, Golovina, Elena S, Kadieva, Madina G, Koryakova, Angela G, Kysil, Volodymyr M, Mitkin, Oleg D, Okun, Ilya M, Tkachenko, Sergey E, Vorobiev, Anton A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - chemistry Amines - pharmacology Cell Line Crystallography, X-Ray ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - antagonists & inhibitors Humans Models, Molecular Molecular Structure Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Radioligand Assay Receptors, Serotonin - metabolism Serotonin 5-HT2 Receptor Antagonists Serotonin Antagonists - chemical synthesis Serotonin Antagonists - chemistry Serotonin Antagonists - pharmacology Structure-Activity Relationship Sulfones - chemical synthesis Sulfones - chemistry Sulfones - pharmacology
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