Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

The antimalarial drug methylene blue (MB) affects the redox behaviour of parasite flavin‐dependent disulfide reductases such as glutathione reductase (GR) that control oxidative stress in the malaria parasite. The reduced flavin adenine dinucleotide cofactor FADH2 initiates reduction to leucomethyle...

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Veröffentlicht in:	ChemMedChem 2010-08, Vol.5 (8), p.1282-1299
Hauptverfasser:	Haynes, Richard K., Chan, Wing-Chi, Wong, Ho-Ning, Li, Ka-Yan, Wu, Wai-Keung, Fan, Kit-Man, Sung, Herman H. Y., Williams, Ian D., Prosperi, Davide, Melato, Sergio, Coghi, Paolo, Monti, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - chemistry Antimalarials - pharmacology artemisinins Artemisinins - chemistry Artemisinins - pharmacology Crystallography, X-Ray flavins Flavins - chemistry flavoenzymes Glutathione Reductase - metabolism malaria Methylene Blue - analogs & derivatives Methylene Blue - chemistry Methylene Blue - pharmacology Molecular Conformation Oxidation-Reduction oxidative stress Protozoan Proteins - metabolism Reactive Oxygen Species - metabolism Structure-Activity Relationship
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