High-Density Lipoproteins Suppress Chemokines and Chemokine Receptors In Vitro and In Vivo

OBJECTIVE—To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX3CL1) and chemokine receptor (CCR2 and CX3CR1) expression, a mechanism for the atheroprotective properties of HDLs. METHODS AND RESULTS—Apolipoprotein (apo) E mice were fed a high-fat diet for 12...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2010-09, Vol.30 (9), p.1773-1778
Hauptverfasser:	Bursill, Christina A, Castro, Maria L, Beattie, Douglas T, Nakhla, Shirley, van der Vorst, Emiel, Heather, Alison K, Barter, Philip J, Rye, Kerry-Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein A-I - administration & dosage Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Cardiology. Vascular system Cells, Cultured Chemokine CCL2 - metabolism Chemokine CCL5 - metabolism Chemokine CX3CL1 - metabolism Chemokines - blood Chemokines - metabolism Chemotaxis, Leukocyte Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Down-Regulation Endothelial Cells - drug effects Endothelial Cells - immunology Endothelial Cells - metabolism Fundamental and applied biological sciences. Psychology Humans I-kappa B Proteins - metabolism Injections, Intravenous Isoxazoles - pharmacology Lipoproteins, HDL - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Monocytes - drug effects Monocytes - immunology Monocytes - metabolism NF-KappaB Inhibitor alpha Phosphorylation Platelet PPAR gamma - drug effects PPAR gamma - metabolism Receptors, CCR2 - metabolism Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Receptors, Interleukin-8A - metabolism RNA, Messenger - metabolism Sulfones - pharmacology Transcription Factor RelA - metabolism
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Zusammenfassung:	OBJECTIVE—To investigate whether high-density lipoproteins (HDLs) suppress chemokine (CCL2, CCL5, and CX3CL1) and chemokine receptor (CCR2 and CX3CR1) expression, a mechanism for the atheroprotective properties of HDLs. METHODS AND RESULTS—Apolipoprotein (apo) E mice were fed a high-fat diet for 12 weeks. Before being euthanized, the mice received 5 consecutive daily injections of lipid-free apoA-I, 40 mg/kg, or saline (control). The injection of apoA-I reduced CCR2 and CX3CR1 expression in plaques compared with controls (P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.110.211342