Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists

The synthesis and SAR of 3-alkyl-4-aryl-4,5-dihydropyrazole-1-carboxamides 1-23 and 1-alkyl-5-aryl-4,5-dihydropyrazole-3-carboxamides 24-27 as two novel cannabinoid CB(1) receptor agonist classes were described. The target compounds elicited high affinities to the CB(1) as well as the CB(2) receptor...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-09, Vol.20 (17), p.4992-4998
Hauptverfasser:	LANGE, Jos H. M, ATTALI, Amos, VAN DER NEUT, Martina A. W, WALS, Henri C, MULDER, Arie, ZILAOUT, Hicham, DUURSMA, Ate, VAN AKEN, Hans H. M, VAN VLIET, Bernard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pyrazoles - chemistry Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - agonists
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