SRMS142-based solid lipid microparticles: Application in oral delivery of glibenclamide to diabetic rats

Enhanced solubility and bioavailability of glibenclamide from SLMs based on P90Gylated-Softisan® 142 matrices (SRMS142). P90Gylation refers to the modification of lipid molecules by one or more phospholipid chains. Phospholipon® 90G (P90G) contains about 94.0% of phosphatidylcholine stabilized with...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2010-09, Vol.76 (1), p.68-74
Hauptverfasser:	Nnamani, P.O., Attama, A.A., Ibezim, E.C., Adikwu, M.U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Ascorbic Acid - analogs & derivatives Ascorbic Acid - chemistry Biological and medical sciences Blood Glucose - drug effects Calorimetry, Differential Scanning Chemistry, Pharmaceutical Delayed-Action Preparations Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Disease Models, Animal Drug Carriers Drug Compounding General pharmacology Glibenclamide Glyburide - administration & dosage Glyburide - chemistry Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - chemistry Male Medical sciences P90Gylation Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylcholines - chemistry Rats Rats, Wistar Solid lipid microparticles Solubility SRMS142 Technology, Pharmaceutical - methods
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