LC–MS/MS studies of ritonavir and its forced degradation products

Forced degradation of ritonavir (RTV), under the conditions of hydrolysis (acidic, basic and neutral), oxidation, photolysis and thermal stress as prescribed by ICH was studied using LC–MS/MS. Eight degradation products were formed and their separation was accomplished on Waters XTerra ® C 18 column...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2010-12, Vol.53 (4), p.833-842
Hauptverfasser:	Rao, R. Nageswara, Ramachandra, B., Vali, R. Mastan, Raju, S. Satyanarayana
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Antiretroviral Biological and medical sciences Chromatography, High Pressure Liquid - methods Chromatography, Liquid - methods Drug Stability Forced degradation Fragment ions Fundamental and applied biological sciences. Psychology General pharmacology HIV Protease Inhibitors - analysis HIV Protease Inhibitors - chemistry Hydrolysis LC–APCI–MS/MS Medical sciences Pharmacology. Drug treatments Ritonavir Ritonavir - analysis Ritonavir - chemistry Tandem Mass Spectrometry - methods
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