A Mechanism of Release of Calreticulin from Cells During Apoptosis

Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone responsible for glycoprotein folding and Ca2+ homeostasis. CRT also has extracellular functions, e.g. tumor and apoptotic cell recognition and wound healing, but the mechanism of CRT extracellular release is unknown. Cytosolic localizatio...

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Veröffentlicht in:	Journal of molecular biology 2010-09, Vol.401 (5), p.799-812
Hauptverfasser:	Tarr, Joanna M., Young, Philip J., Morse, Robert, Shaw, Debra J., Haigh, Richard, Petrov, Peter G., Johnson, Steven J., Winyard, Paul G., Eggleton, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Base Sequence Calreticulin - metabolism calreticulin–phosphatidylserine interaction cell recognition DNA Primers endoplasmic reticulum HeLa Cells Humans Jurkat Cells Microscopy, Fluorescence Phosphatidylserines - metabolism Polymerase Chain Reaction protein secretion Subcellular Fractions - metabolism
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