PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1

Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-beta1 is associated with drug resistance in pancreatic cancer. Pancreatic cancer BxPC3 cells were stably transfected with TGF-beta1 cDNA. Cellular morphology and cell...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2010-08, Vol.29, p.104-104
Hauptverfasser:	Chen, Ying, Yu, Guanzhen, Yu, Danghui, Zhu, Minghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis - drug effects Blotting, Western Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Drug Resistance, Neoplasm Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Humans Immunoenzyme Techniques Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Protein Kinase C-alpha - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Transforming Growth Factor beta - antagonists & inhibitors Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - pharmacology Subtraction Technique Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Tumor Cells, Cultured
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